Original ArticlesAntiepileptic Drugs in Posttraumatic Stress DisorderIancu, Iulian*; Rosen, Yitzhak*; Moshe, Kotler†Author Information *The Psychiatric Division, Sheba Medical Center, Tel Hashomer, and †The Beer Yaakov Psychiatric Hospital, both affiliated with the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel Address correspondence and reprint requests to Dr. Iancu Iulian, Psychiatric Department C., Sheba Medical Center, Tel Hashomer, Israel. E-mail: IULIAN1@BEZEQINT.NET. Clinical Neuropharmacology: July-August 2002 - Volume 25 - Issue 4 - p 225-229 Buy Abstract Antiepileptic drugs might be effective in the treatment of patients with Posttraumatic Stress Disorder, a condition with unmet pharmacologic needs. We review the literature on the efficacy and tolerability of antiepileptic drugs in Posttraumatic Stress Disorder, both case reports and open studies, as well as controlled studies if available. The results of the studies will be presented together with their methodological limitations (e.g., open trials, use of additional medications, and lack of use of standardized scales for Posttraumatic Stress Disorder). The effects of antiepileptic drugs on kindling, a suggested pathogenesis for Posttraumatic Stress Disorder are overviewed, and suggestions for further research are raised. © 2002 Lippincott Williams & Wilkins, Inc.