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Amoxapine Shows an Antipsychotic Effect but Worsens Motor Function in Patients with Parkinson's Disease and Psychosis

Sa, Daniel S.*; Kapur, Shitij; Lang, Anthony E.*

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Amoxapine, a dibenzoxazepine antidepressant, has been suggested to have atypical antipsychotic properties. We tested it to control psychosis in three patients with Parkinson's disease (PD). Two patients had significant improvement in hallucinations, whereas the third could not tolerate the drug for a sufficient period. All three patients experienced a decline in motor function; two also had concomitant reduction in dyskinesias. Therefore, although we found some support for amoxapine having antipsychotic properties, this drug seems to carry a risk of worsening motor function in patients with PD.

*Movement Disorders Unit, Division of Neurology, Toronto Western Hospital, and †PET Center and the Schizophrenia Program, Center for Addictions and Mental Health, University of Toronto, Toronto, ON, Canada

Address correspondence and reprint requests to Anthony E. Lang, 399 Bathurst St., MP 11–301, Toronto, ON, Canada M5T 2S8.

© 2001 Lippincott Williams & Wilkins, Inc.