Original ArticlesThe Effect of Amantadine on Levodopa-induced Dyskinesias in Parkinson's Disease: A Double-blind, Placebo-controlled StudySnow, Barry J.; Macdonald, Lorraine; Mcauley, David; Wallis, WilliamAuthor Information Department of Neurology, Auckland Hospital, Auckland, New Zealand Address correspondence and reprint requests to Barry J. Snow, Department of Neurology, Auckland Hospital, Private Bag 92024, Auckland, New Zealand. Clinical Neuropharmacology: March-April 2000 - Volume 23 - Issue 2 - p 82-85 Buy Abstract We performed a double-blind, placebo-controlled, crossover study to assess the effect of amantadine versus placebo on levodopa-induced dyskinesias in Parkinson's disease. We found a 24% reduction in the total dyskinesia score after amantadine administration (p = 0.004). This improvement was achieved without any influence on the severity of “on” period parkinsonism. The results confirm that amantadine reduces levodopa dyskinesias and support the hypothesis that dyskinesias can be reduced by blockade of excitatory pathways in the basal ganglia. © 2000 Lippincott Williams & Wilkins, Inc.