Brief ReportsImmunoglobulins Are Effective in Pontine MyelinolysisFinsterer, Josef*; Engelmayer, Elfriede*; Trnka, Elisabeth*; Stiskal, Michael†Author Information *Neurological Department, Neurological Hospital Rosenhügel, and Radiological Department, Municipal Hospital Lainz, Vienna, Austria Address correspondence and reprint requests to Josef Finsterer, Postfach 348, 1180 Wien, Austria. Clinical Neuropharmacology: March-April 2000 - Volume 23 - Issue 2 - p 110-113 Buy Abstract Although the exact pathogenesis of central pontine myelinolysis (CPM) is unknown, correction of hyponatriemia, thyreotropin releasing hormone, plasmapheresis, and corticosteroids seem to be effective. Assuming intravenous immunoglobulins (IVIG) to also be effective in CPM, 0.4 g/kg body weight/d immunoglobulins were applied to a 48-year-old patient who developed CPM with double vision, dysarthria, dysphagia, and left-sided hemiparesis 3 weeks after spontaneous normalization of hyponatriemia. After 5 days of IVIG, his symptoms markedly improved, confirmed by improvement in the Norris score (42%), Frenchay score (19%), Kurtzke score (20%), Disability score (54%), vital capacity (26%), and peak torque (69%). The promising clinical effect of IVIG was assumed to be caused by the reduction of myelinotoxic substances, the development of antimyelin antibodies, and the promotion of remyelination. In conclusion, IVIG appear to be a promising therapeutic option in CPM. © 2000 Lippincott Williams & Wilkins, Inc.