Original ArticlesLack of Residual Sedation Following Middle-of-the-Night Zaleplon Administration in Sleep Maintenance InsomniaWalsh, James K.*†; Pollak, Charles P.‡; Scharf, Martin B.§; Schweitzer, Paula K.*; Vogel, Gerald W.∥Author Information *Sleep Medicine and Research Center, St. Luke's Hospital; †Department of Psychiatry, Saint Louis University, St. Louis, Missouri; ‡Division of Sleep Medicine, Department of Neurology, Ohio State University, Columbus; §Center for Research in Sleep Disorders, Cincinnati, Ohio; ∥Sleep Research Laboratory, Inc., and Department of Psychiatry, Emory University, Atlanta, Georgia, USA Address correspondence and reprint requests to James K. Walsh, Sleep Medicine and Research Center, St. Luke's Hospital, 232 S. Woods Mill Road, Chesterfield, MO 63017, USA. Clinical Neuropharmacology: January-February 2000 - Volume 23 - Issue 1 - p 17-21 Buy Abstract The present randomized, double-blind, placebo and active-drug controlled, crossover study assessed residual sedation after zaleplon 10 mg, flurazepam 30 mg (as an active control), and placebo, taken during a nocturnal awakening in patients with sleep maintenance insomnia. Twenty-two healthy sleep maintenance insomniacs (11 men; mean age, 42 y) received zaleplon, flurazepam, or placebo after an experimental awakening 3.5 hours after bedtime on two consecutive nights in each of three conditions. Residual sedation was measured with sleep latency testing (5 and 6.5 h postdrug), digit symbol substitution, symbol copying, and subjective sleepiness by visual analog scale, each twice each morning. Zaleplon did not differ from placebo on any measure of residual sedation; flurazepam showed significant sedation on all measures. No residual sedative effects were detected 5 or 6.5 hours after ingestion of zaleplon during the middle of the night by sleep maintenance insomniacs. © 2000 Lippincott Williams & Wilkins, Inc.