Original ArticlesCombined Electroconvulsive-Clozapine TherapyKupchik, Marina*; Spivak, Baruch*†; Mester, Roberto*†; Reznik, Ilya‡; Gonen, Noah*†; Weizman, Abraham†§; Kotler, Moshe∥Author Information *Ness Ziona Mental Health Center, Ness Ziona; †Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; ‡Abarbanel Mental Health Center, Bat Yam; §Geha Psychiatric Hospital, Petah Tikva; ∥Faculty of Medicine, Ben Gurion University, Beer Sheva, Israel Address correspondence and reprint requests to Baruch Spivak, Ness Ziona Mental Health Center, P.O. Box 1, Ness Ziona 74100, Israel. Clinical Neuropharmacology: January-February 2000 - Volume 23 - Issue 1 - p 14-16 Buy Abstract We reviewed 36 reported psychiatric patients who were treated with a combination of electroconvulsive therapy (ECT) and clozapine. The indication of the ECT-clozapine treatment was resistance to classical antipsychotic agents, clozapine, or ECT alone. Sixty-seven percent of the patients benefited from the combined treatment. In most of the patients, the combined treatment was safe and well tolerated. Adverse reactions occurred in 16.6% of the patients and included prolonged ECT-induced seizures (one case), supraventricular (one case) and sinus tachycardia, and blood pressure elevation. It seems that combined ECT-clozapine treatment is effective and safe. This strategy may be a therapeutic option in treatment-resistant patients. © 2000 Lippincott Williams & Wilkins, Inc.