ORIGINAL CONTRIBUTIONS: PDF OnlySternic Nadezda; Kacar, Aleksandra; Filipovic, Sasa; Svetel, Marina; Kostic, Vladimir S.Clinical Neuropharmacology: March-April 1998 - p 93-96 Buy Abstract Summary In this open study, the therapeutic effect of moclobemide, a reversible selective monoamine oxidase A inhibitor, was tested in 20 patients with Parkinson's disease who developed levodopa-induced motor response complications. Moclobemide as adjunct therapy reduced “off” time duration for 27%, without an overall motor and functional improvement during their “on” periods. Since it was well tolerated, moclobemide may be specially indicated in elderly or depressed fluctuating parkinsonian patients. © Williams & Wilkins 1998. All Rights Reserved.