Thirty-one patients, aged 12.6 ± 5.6 years, with refractory seizures for 8 ± 4.3 years, were treated with adjunctive vigabatrin. Twenty-four percent had a >50% reduction in seizure frequency (95% one-sided confidence interval). Generalized myoclonic, atonic, and tonic clonic and partial, with and without secondary generalization, seizures were all reduced at a mean dose of 70 ± 38 mg/kg/day. Comparison of vigabatrin therapy duration, for partial and generalized seizure groups, utilizing Kaplan-Meier methodology showed similar survival times. Vigabatrin therapy was ineffective in the four children with tuberous sclerosis. Transient somnolence, ataxia and dizziness were the most frequent side effects. A severe aggressive agitation occurred in three patients, and necessitated discontinuation of vigabatrin in one patient. Vigabatrin was as effective in generalized as in partial seizures in this study. Clinical utility may be limited by unacceptable behavioral side effects in some patients.
Address correspondence and reprint requests to Dr. R. D. Sheth at Department of Neurology and Pediatrics, Box 9180, West Virginia University, Health Science Center, Morgantown, WV 26506-9180, U.S.A.
This article was presented in part at the 1995 Annual Meeting of the American Epilepsy Society.
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