Brief Report: PDF OnlyHelveston Wendell; Cibula, Jean E.; Hurd, Russell; Uthman, Basim M.; Wilder, B. J.Clinical Neuropharmacology: June 1996 - p 271-275 Buy Abstract Summary: We report a patient with Friedreich's disease (FD) who exhibited abnormalities of antioxidant metabolism, including decreased levels of glutathione peroxidase, glutathione reductase, and selenium, and an increased lipid peroxide index. These abnormalities became normal after treatment with N-acetylcysteine, selenium, and low-dose vitamin E therapy. Treatment was associated with a decreased rate of clinical decline. FD is a neurodegenerative disorder that may be related to disturbed antioxidant metabolism; the disorder may be treatable with antioxidant compounds. Address correspondence and reprint requests to Dr. B. J. Wilder at Veterans Administration Medical Center, 1601 S. W. Archer Road, Gainesville, FL 32608-1197, U.S.A. © Williams & Wilkins 1996. All Rights Reserved.