Articles: PDF OnlyBelmaker R. H.; Agam, G.Clinical Neuropharmacology: 1995 - p S34-S38 Buy Abstract Summary: Many social and cultural influences have an impact on suicide rates in different countries. Schizophrenia is a risk factor for suicide, and care should be taken that suicide prevention measures and treatment do not adversely impinge on the patient's quality of life. Serotonergic dysfunction and the phosphoinositide system may be correlated with suicide. The possible role of inositol monophosphatase as a second messenger was investigated in schizophrenic patients and controls, and it was found that inositol monophosphatase activity is significantly higher in schizophrenic patients. Further studies are needed to investigate the possibility that this is a primary abnormality in schizophrenia that leads to serotonergic dysfunction. Address correspondence and reprint requests to Dr. R. H. Belmaker at Division of Psychiatry, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel. © Williams & Wilkins 1995. All Rights Reserved.