Articles: PDF OnlyStockmeier C. A.; Meltzer, H. Y.Clinical Neuropharmacology: 1995 - p S9-S17 Buy Abstract Summary: Abnormal serotonergic function has been reported in schizophrenia, depression, and suicide. Decreased levels of the serotonin (5-HT) metabolite 5-hydroxyindoleacetic acid have been found in the cerebrospinal fluid of some patients with suicidal behavior. Decreased binding to 5-HT2A receptors in the prefrontal cortex has been reported in patients with schizophrenia, but varying results have been recorded in suicide victims. 5-HT1A receptor binding and 5-HT transporters may also be altered in suicidal and nonsuicidal patients with schizophrenia. Abnormalities have also been reported in the hypothalamo-pituitary-adrenal (HPA) axis, and there is evidence that schizophrenic patients have increased plasma cortisol output. It is interesting to note that clozapine, an antipsychotic that reduces suicidality, binds to 5-HT2A receptors and decreases cortisol output. Normalization of the interaction between the HPA axis and serotonergic function may therefore be important in reducing suicidality. Address correspondence and reprint requests to Dr. C. Stockmeier at Department of Psychiatry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-5000, U.S.A. © Williams & Wilkins 1995. All Rights Reserved.