Articles: PDF OnlyGittelman Klein RachelClinical Neuropharmacology: 1995 - p S7-S14 Buy Abstract Summary: This article reviews the more recent literature that addresses the separation anxiety hypothesis, i.e., the relationship between childhood separation anxiety and adult panic disorder. The three major approaches have consisted of retrospective reports of childhood anxiety obtained from adults with panic disorder, studies of cross-generational familial aggregation of the two disorders, and the prospective longitudinal study of childhood separation anxiety disorder into adulthood. The evidence is mixed, but the most relevant study of long-term outcome of childhood separation anxiety is consistent with the hypothesis. Address correspondence and reprint requests to Dr. R. G. Klein at New York State Psychiatric Institute #80, 722 West 168th Street, New York, NY 10032, U.S.A. © Williams & Wilkins 1995. All Rights Reserved.