Articles: PDF OnlyQuinn N. P.Clinical Neuropharmacology: 1994 - p S43-S49 Buy Abstract Summary: Much has been written concerning whether to begin levodopa treat-ment early or late in patients with Parkinson's disease (PD), and the debate will probably continue for many years. In this article I shall present my personal perspective on this issue. In older patients I can see little cause to delay levodopa therapy. However, I submit that the shorter latency to develop more frequent and severe fluctuations and, particularly, dyskinesias in patients with young-onset PD argues in favor of delaying levodopa therapy, provided that in the interim the symptoms and signs of the disease can be adequately managed using other therapies. Address correspondence to Dr. N. P. Quinn at National Hospital, Institute of Neurology, Queen Square, London WC1N 3BG, England. © Williams & Wilkins 1994. All Rights Reserved.