Article: PDF OnlyGeerts S.; Bruynooghe, F.; De Cuyper, H.; Demeulemeester, F.; Haazen, L.Clinical Neuropharmacology: 1994 - p S50-S57 Buy Abstract Summary: The efficacy and tolerability of moclobemide (300 or 600 mg daily) and fluoxetine (20 or 40 mg daily) were compared in a 6-week, double-blind study of 25 inpatients and 24 outpatients who had major depressive episodes without psychotic features (DSM-III-R). Although the clinical results of this study suggest better efficacy with moclobemide and better tolerability with fluoxetine, a statistically significant difference between treatment groups was noted only with respect to Clinical Global Impressions recorded after 10 days of therapy; these were significantly better in the moclobemide group. A daily dosage of 300 mg of moclobemide and 20 mg of fluoxetine would thus appear to be comparable both in antidepressant efficacy and tolerability. Address correspondence and reprint requests to Dr. S. Geerts at St. Lucas General Hospital, St. Lucaslaan 29-8310 Assebroek, Belgium. © Williams & Wilkins 1994. All Rights Reserved.