Original Contributions: PDF OnlyKuno Sadako; Mizuta, Eiji; Nishida, Junko; Takechi, MinakoClinical Neuropharmacology: October 1992 - p 381-386 Buy Abstract Summary The effect of arotinolol, a peripherally acting β-adrenergic-blocking agent, on postural or kinetic tremor was studied in monkeys with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Male cynomolgus monkeys (Macaca fascicularis) were treated with three injections of MPTP hydrochloride (0.3 mg/kg, i.v.) at an interval of 3–4 days, followed by several injections of the same dose every 7 days. Four monkeys with persistent parkinsonian symptoms manifested for >1 year were used. The animals developed mild to moderate degrees of postural or kinetic tremor, and their motor activity was reduced. Arotinolol (20–30 mg/kg, s.c.) significantly suppressed postural tremor in a dose-dependent manner. Propranolol (20–30 mg/kg) was also effective in suppressing the tremor. However, the application of propranolol induced emesis, whereas arotinolol had no adverse effects. These results suggest that arotinolol is a useful adjunct to dopaminergic therapy for tremor in Parkinson's disease. © Williams & Wilkins 1992. All Rights Reserved.