Brief Report: PDF OnlyMontastruc J. L.; Rascol, O.; Montastruc, P.Clinical Neuropharmacology: October 1992 - p 404-407 Buy Abstract Summary Intravenous injection of low doses of naloxone was found to reverse the respiratory depression induced by apomorphine in chloralose-anesthetized dogs. Similar results were obtained with haloperidol, whereas yohimbine remained ineffective. These data, suggest that apomorphine depresses respiratory rate through a mechanism involving both dopamine and opiate mechanisms but not α2-adrenoceptors. Respiratory arrest induced by overdosages of apomorphine can be treated with naloxone. © Williams & Wilkins 1992. All Rights Reserved.