Original Contributions: PDF OnlyAstarloa R.; Mena, M. A.; Sánchez, V.; de la Vega, L.; de Yébenes, J. G.Clinical Neuropharmacology: October 1992 - p 375-380 Buy Abstract Summary In this study, the effects of a diet rich in insoluble fiber (DRIF) on motor disability and the peripheral pharmacokinetics of orally administered L-dopa in Parkinsonian patients with marked constipation are analyzed. We found a useful effect of a DRIF on plasma L-dopa concentration and motor function. The greatest effect on the plasma L-dopa levels was found early (at 30 and 60 min) after oral administration. There was a relationship between the improvement of constipation and the higher bioavailability of L-dopa. DRIF can be a coadjutant treatment in patients with Parkinson's disease. © Williams & Wilkins 1992. All Rights Reserved.