Brief Report: PDF OnlyA Double-Blind, Controlled Study of High-Dose L-Deprenyl in the Treatment of Parkinson's DiseaseFrankel, Jonathan P.; Kempster, Peter A.; Stibe, Catarina M. H.; Eatough, Virginia M. H.; Nathanson, Michael; Lees, Andrew J.; Stern, Gerald M. Author Information Department of Neurology, University College and Middlesex Hospitals, School of Medicine, London, U.K. Clinical Neuropharmacology 12(5):p 448, October 1989. Buy Abstract The conventional dose of deprenyl used in Parkinson's disease is 10 mg/day, having been established by in vitro platelet studies and clinical evaluation. Twelve patients with Parkinson's disease on treatment with L-dopa who showed evidence of wearing-off effects or motor oscillation were studied in a double-blind, placebo-controlled, crossover trial to compare conventional doses of deprenyl with higher doses (up to 40 mg/day) and placebo. We did not find higher doses of deprenyl to be superior to conventional doses and in 17% of cases treatment had to be withdrawn because of side effects. © Williams & Wilkins 1989. All Rights Reserved.