Original Contributions: PDF OnlyColeman R. J.; Temlett, J. A.; Quinn, N. P.; Stahl, S. M.; Marsden, C. D.Clinical Neuropharmacology: February 1989 - p 37-45 Buy Abstract Summary We describe a simple quantitative bedside method for assessing the dopaminergic properties of new therapeutic agents, namely, by documenting their duration of action in patients with Parkinson's disease who exhibit “on-off' fluctuations. This model represents a form of human dopaminergic “bioassay”. © Williams & Wilkins 1989. All Rights Reserved.