Articles: PDF OnlyA Comparative Study of Conventional and Controlled-Release Formulations of Trazodone in Elderly Depressed PatientsBayer, A. J.; Pathy, M. S. J.; Cameron, A.*; Venkateswalu, T.†; Ather, S. A.‡; Mankikar, G. D.§; Ghosh, A. K.∥Author Information University Department of Geriatric Medicine, Cardiff Royal Infirmary, Newport Road, Cardiff, *Department of Psychiatry, Middleton Hospital, Ilkely, Yorkshire, †Department of Mental Health for the Elderly, St. Anne's House, St. Leonards-on-Sea, Sussex, ‡Department of Geriatric Medicine, Pindersfield Hospital, Wakefield, West Yorkshire, §Department of Geriatric Medicine, Brighton General Hospital, Brighton, Sussex, and ∥Medical Department for the Elderly, Pontefract General Infirmary, Friarwood Lane, Pontefract, West Yorkshire, England Address correspondence and reprint requests to Dr. A. J. Bayer, University Department of Geriatric Medicine, Cardiff Royal Infirmary, Newport Road, Cardiff, CF2 1SZ, England. Clinical Neuropharmacology: Volume 12 - Issue - p S50-S55 Buy Abstract Summary: One hundred sixty-six elderly depressed patients were recruited from six hospital centers and entered in a double-blind, randomized, parallel group comparative study of conventional and controlled-release formulations of trazodone. Patients received a single nighttime dose of 100 mg for 1 week, followed by 3 weeks of 200 mg or less, depending upon tolerance. Efficacy was measured using the modified Hamilton depression rating scale and global assessments of the severity of depression and improvement relative to baseline. Both treatments were equally effective with 39 (68%) patients completing 4 weeks of treatment with the conventional formulation and 41 (77%) patients completing 4 weeks treatment with the controlled-release formulation rated as very much improved. Sleep improved shortly after initiation of treatment in most patients and there were no significant differences between groups. There was a tendency for fewer side effects to be recorded during the first week of treatment in patients receiving the controlled-release formulation but no difference reached statistical significance. © Williams & Wilkins 1989. All Rights Reserved.