^aLee Kong Chian School of Medicine

^bGenetics Service

^cRespiratory Medicine Service, Department of Paediatrics

^dCardiology Service, Department of Paediatric Subspecialties, KK Women’s and Children’s Hospital

^eGenome Institute of Singapore

^fCardiovascular Research Institute, National University of Singapore, National University Health System, Singapore, Singapore.

Received 22 August 2017 Accepted 13 February 2019

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Correspondence to Saumya Shekhar Jamuar, MBBS, MRCPCH, Department of Paediatrics, KK Women’s and Children’s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore, Tel: +65 63941129; fax: +65 62917923; e-mail: saumya.s.jamuar@singhealth.com.sg