^aMolecular and Clinical Sciences Institute, St George’s, University of London, London, UK

^bDepartment of Biomedicine and Prevention, University of Rome Tor Vergata

^cIRCCS Neuromed, Pozzilli (IS)

^dDepartment of Medical Laboratory, Laboratory of Medical Genetics, Tor Vergata Hospital, Rome, Italy

^eDepartment of Radiology, Quaem Hospital

^fCenter of Excellence in Medical Education Technology

^gDepartment of Medical Genetics, University of Medical Sciences, Mashhad, Iran

^hDepartment of Pediatrics, University of Lausanne and Lausanne University Hospital, Lausanne, Switzerland

Correspondence to Maria Rosaria D’Apice, PhD, Tor Vergata Hospital, Viale Oxford, 81, 00133 Rome, Italy Tel: +39 067 259 6072; fax: +39 2090 0669; e-mail: [email protected]