A second case of tetrasomy 20p due to an additional isochromosome 20p is reported. This resulted in a spontaneous intrauterine death with multiple congenital abnormalities. In keeping with the previous report, the foetus had poor ossification resulting in multiple long bone fractures.
Departments of aClinical Genetics
cRadiology, Royal Liverpool Children's Hospital
dDepartment of Obstetrics, Countess of Chester Hospital
eDepartment of Cytogenetics, Liverpool Women's Hospital
Correspondence and requests for reprints to Dr. Fryer, Department of Clinical Genetics, Royal Liverpool Children's Hospital (Alder Hey), Eaton Road, Liverpool L12 2AP, England
Tel: +44 151 252 5904; fax: +44 151 252 5951;
Received 31 August 2004 Accepted 5 September 2004