ORIGINAL ARTICLESCongenital cardiac disease as a core feature of cranio-osteoarthropathyO'Connell, Susana; Suri, Mohnishb; Duff, Desmonda; Kelleher, Jeremiaha; Hall, Christine Mc; Reardon, WilliamaAuthor Information aOur Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland bClinical Genetic Service, City Hospital, Nottingham, UK cGreat Ormond Street Hospital for Children, London, UK Correspondence and requests for reprints to Dr Reardon, National Centre for Medical Genetics, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland Tel: +353 1 409 6811; e-mail: firstname.lastname@example.org Received 2 April 2004 Accepted 29 June 2004 Clinical Dysmorphology: October 2004 - Volume 13 - Issue 4 - p 213-219 Buy Abstract Cranio-osteoarthropathy is a rare condition. Classically, signs are identifiable in infancy with clubbing of fingers, and delayed closure of the clinically enlarged cranial sutures, followed by periosteal new bone formation on X-rays of the long bones. Ultimately, joint swelling and stiffness follow, typically involving the large joints. We report two unrelated patients with features of cranio-osteoarthropathy, both of whom also had a history of congenital heart disease. Moreover, the cases reported here, manifesting significant differences in radiological features, emphasize the variability of radiological findings which can attend this condition. © 2004 Lippincott Williams & Wilkins, Inc.