LETTERS TO THE EDITORSType 1 Arnold–Chiari malformation and Noonan syndrome. A new diagnostic feature?Holder-Espinasse, Muriel; Winter, Robin M.Author Information Clinical Genetics Unit, Institute of Child Health, London, UK Correspondence and request for reprints to Robin Winter, Clinical and Molecular Genetics Unit, Institute of Child Health, 30 Guildford street, London WC1N 1EH, UK Tel: +44 20 7905 2647; Fax: +44 20 7813 8141; e-mail: [email protected] Received 10 April 2003 Accepted 27 May 2003 Clinical Dysmorphology: October 2003 - Volume 12 - Issue 4 - p 275 Buy Abstract Noonan syndrome is a clinically and genetically heterogeneous genetic condition. Arnold–Chiari malformation has been previously reported in three cases of Noonan syndrome. We describe a fourth case with this association. We suggest that brain and cervical spine MRI should be performed if neurological symptoms are present. © 2003 Lippincott Williams & Wilkins, Inc.