ARTICLE: PDF OnlyUnusual association of congenital malformations craniosynostosis, heart defect, abnormal intestinal innervation and urogenital abnormalitiesVan Nesselrooij, B. P. M.; Spliet, W.; Beemer, F. A.Author Information Clinical Genetics Center Utrecht, PO Box 18009, 3501 CA Utrecht, The Netherlands; Department of Pathology, University Hospital Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands Clinical Dysmorphology: January 1998 - Volume 7 - Issue 1 - p 51-54 Buy Abstract Monozygotic male twins and an unrelated boy are described who have an unusual association of malformations, i.e. craniosynostosis of the sagittal suture, a cardiac malformation, urogenital anomalies, intestinal malformations and a single umbilical artery. The twins are discordant for these features, except for Hirschsprung disease. No similar cases could be traced in literature. The possible genetic background is discussed. © Lippincott-Raven Publishers.