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The Role of Orthokeratology in Myopia Control: A Review

Lipson, Michael J., O.D., F.A.A.O., F.S.L.S.; Brooks, Moya M., M.D.; Koffler, Bruce H., M.D.

doi: 10.1097/ICL.0000000000000520
Review Article

Abstract: The prevalence of myopia and high myopia has significantly increased worldwide and in the United States. The serious implications of these trends are being recognized. Myopia is not just a minor inconvenience requiring vision correction with glasses or contact lenses, but a disease process creating significant risk of serious vision-threatening eye disease. Various methods of treatment for myopia and myopic progression have been prescribed and studied in effort to find one that is effective, safe, and that patients will be compliant with. Numerous peer-reviewed studies have shown orthokeratology (OrthoK) is effective in slowing myopic progression. This review article covers the development of OrthoK, its mechanism of action, its evolution, and refinement from a refractive option to its use as a mean of slowing myopic progression. After detailing patterns of myopia progression, a description of theories and studies as to how OrthoK slows myopia progression in children is also explained. The review will focus on progression of myopia and the use of OrthoK to slow myopia progression after myopia has been diagnosed.

Department of Ophthalmology and Visual Science (M.J.L.), University of Michigan, Ann Arbor, MI; and Koffler Vison Group (B.H.K.), Lexington, KY.

Address correspondence to Michael J. Lipson, O.D., F.A.A.O., Department of Ophthalmology and Visual Science, University of Michigan, 39901 Traditions Drive, Suite 230, Northville, MI 48168; e-mail: mjlipson@umich.edu.

M. Lipson is a consultant to Bausch and Lomb's Specialty Vision Products division. B. Koffler is on the speaker's bureau for Paragon Vision Sciences and Bausch and Lomb. The author has no funding or conflicts of interest to disclose.

Accepted April 05, 2018

Prevalence of myopia is increasing dramatically in East Asia, in the United States, and worldwide.1,2 Myopia is being diagnosed at younger ages and is progressing to higher degrees. Implications of these trends for the future are serious.3 It is not just that more people will be dependent on glasses or contact lenses, but that more people will be faced with vision-threatening eye disease such as myopic macular degeneration, central and peripheral retinal pathology, and glaucoma and cataract, as a result of complications related to longer axial length and increasing myopia.4 But, numerous studies show that we can provide interventions with the ability to slow myopic progression.5 This review will cover the epidemiology of myopia, risk factors for development and progression of myopia; provide a description of modern orthokeratology (OrthoK, the use of specially designed rigid gas-permeable (GP) contact lenses worn while sleeping to reshape the cornea and thus the refractive error of the eye), and review the studies demonstrating that OrthoK is a safe and efficacious process not only to correct refractive error, but also to slow progression of myopia.

Various methods of treatment for myopia and myopic progression have been prescribed and studied in effort to find one that is effective, safe, and that patients will be compliant with. Currently, the three methods that have the greatest efficacy are OrthoK, atropine, and specially designed soft lenses.6 This review will focus only on OrthoK. In the United States, overnight OrthoK received Food and Drug Administration (FDA) clearance to correct myopia in 2002. At this time, prescribing OrthoK specifically to stop myopic progression is “off label.” As will be described later, numerous peer-reviewed studies have shown OrthoK is effective in slowing myopic progression.7,8 Even without FDA clearance for an indication of myopia control, most patients report that myopia control is the main reason they became interested in OrthoK.9

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EPIDEMIOLOGY OF MYOPIA/UNITED STATES AND WORLDWIDE

In the United States, myopia prevalence in adults has increased from 25% in 1979% to 41% in 2004.1 More recent studies indicate that trend continues such that, as of 2016, the figure is near 50%.3 Globally, prevalence of myopia in East Asian countries has been reported as high as 90%.10

A notable group of world health experts estimates that, in 2010, there were almost 2 billion people in the world with myopia and project that, with current trends, half of the world population (approximately 5 billion) will be myopic by 2050.2 (Fig. 1) In addition, myopia is being diagnosed at younger ages in many countries.11 Extensive study has shown that children who develop myopia at a younger age tend to progress more quickly and ultimately progress to a higher level of myopia.4,12 Increasing degree of myopia is clinically apparent as the axial length of the eye increases during growth years. Although a thorough review of myopia demonstrated that any degree of myopia is a risk factor for future vision-threatening pathology, high myopia (more than 6.00D) is associated with very high risk of these conditions.4 The higher the degree of myopia, the greater the risk. For example, people with more than 6.00D of myopia have a 14.4 times greater chance of developing glaucoma and a 3.3 times greater chance of developing a posterior subcapsular cataract.4,13 Those with more than 8.00D of myopia have a 7.8 times greater risk of having a retinal detachment. Vision impairment, significantly reduced best-corrected vision, is 22 times more likely in myopia over 10.00D compared with those at 6.00D of myopia.13 With current trends, projections are that more than 900 million of the world's populations will be highly myopic (more than 5.00D) by 2050.2

FIG. 1

FIG. 1

The serious implications of these trends are being recognized. Myopia is not just a minor inconvenience requiring vision correction with glasses or contact lenses, but a disease process creating significant risk of serious vision-threatening eye disease.4,13,14

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PROGRESSION OF MYOPIA

Myopia development and progression are complex and differ among individuals in genetics,15 influence of environmental causes,16 mode of correction,17 outdoor time,18 time spent on near tasks,19 ethnicity,20 and progression patterns.21 Each of these characteristics has been extensively studied. Work on preventing the onset of myopia has been very limited, targeting time spent outdoors as a major contributing factor. This review will focus on progression of myopia, and the use of OrthoK to slow myopia progression after myopia has been diagnosed.

Onset of myopia can be found in newborns, but the majority is seen in school-age children. Jones et al.22 found 3 distinct patterns of myopia of development: first, those first becoming myopic around 6 to 7 years old, then a group developing myopia around 10 to 12, and finally those who first show myopia in their teens, each with their own unique pattern of progression. Studies show that the younger myopia develops, the faster it apparently progresses. Although older children and teens still show myopic progression, the rate of progression slows after 12 to 13 years of age.22 There is no minimum age for starting OrthoK. Cho's 2012 study23 suggests that earlier age of intervention would have greater long-term benefit in limiting the ultimate level of myopia. In that study, 65% of the 7- to 8-year-old children in the spectacle-wearing control group were “fast progressors” versus 20% of the OrthoK group. Practical considerations in how early to prescribe OrthoK include the patient's maturity, motivation, responsibility for compliance in hygiene and lens care, and ability to report problems to eye care providers and parents. Candidacy should be carefully assessed on an individual case basis weighing relative risks versus potential benefits and options for other myopia management modalities.

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HISTORY OF ORTHOKERATOLOGY

The first attempt at corneal manipulation to reduce refractive error can be traced back to the early Chinese who applied small bags of sand to the eyelids thereby reducing corneal curvature and myopia.24 Orthokeratology may be defined as a technique of programmed application of contact lenses to compress or manipulate corneal curvature.25 It was first noted in the 1950s by Wesley and Jessen26 that their patients were experiencing what they called “spectacle blur” caused by reshaping of the cornea after wearing hard contact lenses. Other practitioners, at this time, noted that many myopic contact lens wearers had improvement in visual acuity and/or a reduction in myopic correction after removal of rigid contact lenses.27,28 Although spectacle blur was seen as a nuisance, it was the springboard for later studies. In the 1960s, Jessen29 created the first OrthoK lenses out of polymethylmethacrylate, a hard plastic that did not allow oxygen to pass through the lens, preventing OrthoK from expanding as a common practice. Orthokeratology continued in the 1970s with the use of flat-fitting rigid contact lenses. These lenses were able to reduce myopia only by approximately 1 D and were ineffective at allowing oxygen to pass through the lens, making OrthoK more of a novelty. The late 1970s ushered in a new era of contact lens materials. Rigid GP lenses were designed from new plastic materials that allowed more oxygen to reach the cornea, improving comfort and safety. However, the lenses still remained incapable of effectively correcting myopia, and the OrthoK trend faded.30,31

In 1989, the first reverse geometry lens was designed by Nick Stoyan and Wlodyga.32 The lens was created with the secondary curve of steeper slope than the base curve, accelerating the time for the lens effect to occur, while increasing the ability to correct higher degrees of myopia and improving lens centration.33 Soon after, technological advances included use of higher Dk lens materials (higher oxygen permeability), innovative reverse geometry lens designs, and improved corneal topography. With this additional capability, it became apparent that mapping the entire corneal surface before and after OrthoK treatment was critical to achieving optimal results. Contex Inc. (Sherman Oaks, CA) was able to obtain approval for a daily-wear OrthoK design from the FDA in 1998. Subsequently, other investigators followed with creative designs for better centration and astigmatism control. El-Hage34 is credited with being the first to use corneal topography to fit OrthoK lenses and monitor the resulting corneal changes. Corneal topographer manufacturers developed software allowing captured maps to be analyzed in more and detailed ways for precise design and to monitor corneal changes during OrthoK follow-up. This includes various types of topographical analysis including axial, tangential, elevation, and difference maps. Technology advances currently allow for the use of corneal topography for OrthoK to obtain accurate baseline measurements, determine initial lens selection, design initial lenses, monitor topographic changes after OrthoK lens wear, and accurately monitor lens treatment/position over many years of lens wear. In 2002, the FDA approved an overnight OrthoK design by Paragon Vision Sciences to include all age groups and corrections up to −6 D. Marketed as corneal refractive therapy,35 this approval revitalized the industry. Since then, numerous companies have entered the OrthoK market with creative designs and materials. This has allowed for more customization to enhance lens centration and correct more complex prescriptions. Overnight wear, higher oxygen permeability, computerized lens designs, and accelerated results have created more popularity for OrthoK with eye care professionals and the public.36 Orthokeratology lenses represented more than 5% of the U.S. GP lens market in 2011 and have grown to about 19% in 2016.36 Currently, numerous OrthoK designs have attained FDA clearance in the United States (Table 1) with many others available worldwide.

TABLE 1

TABLE 1

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EVOLUTION OF ORTHOKERATOLOGY FOR MYOPIA CONTROL

As overnight OrthoK became more popular, patients and clinicians observed an apparent reduction or cessation of their myopic progression. The first randomly controlled trial comparing axial length changes in subjects fitted with OrthoK lenses to single-vision spectacle wearers was reported by Cho and Cheung.23 Over a 2-year period, the OrthoK wearers showed a mean axial length increase of 0.29 (SD 0.27) mm vs. 0.54 (0.27) mm (P=0.01) for the spectacle wearers. One study showed a significantly smaller change in the cycloplegic retinoscopy in wearers of OrthoK lenses versus those wearing soft lenses.37 Subsequent studies and meta-analysis studies have confirmed these findings.7,8,17,37–41

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ANATOMICAL/MORPHOLOGICAL CHANGES WITH ORTHOKERATOLOGY

Studies have shown that myopic OrthoK lenses elicit a flattening of the central cornea and a steepening of the mid-peripheral cornea, accompanied by changes to both the epithelial and stromal corneal layers.42–44 This pattern is reversed in hyperopic OrthoK, with steepening centrally and flattening in the mid periphery.45

Far less is known about the mechanisms that elicit these corneal morphological changes. Choo et al. have enumerated many possible mechanisms by which OrthoK lenses may reshape the cornea.46–48

Corneal bending was one of the first proposed mechanisms in which some believed that the entire central cornea, including anterior and posterior curvatures, was altered by reverse geometry lenses. This theory now seems less likely, and new technologies such as optical coherence tomography, Orbscan videokeratography, and the Pentacam Scheimpflug photography system capable of calculating the posterior corneal curvature may be used to better assess the veracity of this postulated mechanism.49–51

Epithelial cell redistribution and pressure differentials beneath the contact lens may result in forces that push against the central cornea and cause the redistribution or migration of epithelial cells to the mid periphery.46 This theory suggests that epithelial cells are mobile but is complicated by what we know about cellular attachments and connections between epithelial cells.52,53

Remodeling or compression of epithelial cells in their local environment because of changing pressures/forces that do not require these cells to migrate from their original site is another theory.47 (Fig. 2).

FIG. 2

FIG. 2

Some have proposed that epithelial cells containing various cytoplasmic components and organelles may actually transfer intercellular components to adjacent cells through intracellular connections such as gap junctions, in response to the presence of OrthoK lenses. “Compressive forces in the central epithelium may induce a movement of intercellular fluid toward the limbus, resulting in smaller cells in the center and enlarged cells in the mid periphery” writes Choo et al.47

Zhong et al.54 found a reduced density of keratocytes in the corneal stroma and a modification of their shape. Another proposed mechanism involves an OrthoK lens–induced alteration of the rate of cellular mitosis, such that there is an increase in cellular proliferation in the mid periphery. Limbal stem cells and/or the basal epithelial layer may play a role in this mitotic theory.54

In addition, OrthoK may induce alterations in cellular sloughing because of changes in apoptosis resulting in an increase in cells in the corneal mid periphery.49 Stromal remodeling may also play a role in long-term OrthoK use and induced corneal changes.47,48 Verifying such changes on a cellular level will be challenging. One or more of these proposed mechanisms may be involved and more research is needed.54

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HOW DOES ORTHOKERATOLOGY SLOW MYOPIC PROGRESSION?

The most accepted theory of myopia progression centers on refractive changes peripheral to the macula. Pioneering work on myopia progression and peripheral refraction was performed with monkeys by Smith et al.55 Studies in humans demonstrate that myopic eyes show relative hyperopia in the periphery that hyperopic and emmetropic eyes do not,56 and children who develop myopia have more relative hyperopic peripheral defocus than emmetropic children two years before the onset of myopia.11 Children with peripheral hyperopic defocus are more likely to develop myopia.56 In addition, myopic children corrected with spectacles show significant hyperopic defocus.57 Therefore, peripheral hyperopia is likely the signal for increased eye growth. Light focusing posterior to the peripheral retina may act as a signal for increasing axial length and higher degree of myopia. With OrthoK, the creation of an oblate shape of the cornea and the junction where the oblate portion of the cornea returns to its original curvature causes the image to focus centrally at the fovea, while peripheral light focuses anterior to the peripheral retina (myopic defocus).58 This results in an image profile focusing centrally at the fovea, while peripheral to the macula, thereby myopic defocus is created. This myopic defocus, shown in Figure 3, is believed to be the mechanism that slows myopia progression during OrthoK wear.55,56,59 Although these studies are quite convincing, there are studies showing no effect of peripheral defocus on axial length increase while other studies show a strong effect.21,60–63 Although clinical research has demonstrated that peripheral myopic defocus created with OrthoK is the significant mechanism by which myopia progression is slowed, other mechanisms may also influence slowing of progression during OrthoK. Another factor may be the change in lag of accommodation.64–67 This change occurs because of the increase in positive spherical aberration created after OrthoK and may be protective against progression of myopia.

FIG. 3

FIG. 3

In addition, researchers have studied changes in choroidal thickness in progressive myopes and during OrthoK wear.68,69 Progressive myopes show thinner choroidal thickness than emmetropes or myopes who are not progressing.70,71 Myopic OrthoK wearers have shown greater choroidal thickness than myopic controls wearing spectacles.71 The mechanism of the effect on choroidal thickness has not been established but shows great potential for future study.

Individual studies and meta-analyses on myopia control with OrthoK have shown a 40% to 60% mean reduction in rate of refractive change compared with controls using spectacles to correct myopia.6–9,36,72–75 It should be noted that studies reporting “mean reduction in rate of myopic progression” are describing the average for all subjects in the study. (Table 2). Within a study showing 50% mean reduction in myopia progression, some individuals may show 100% reduction in refractive change (no progression), whereas others may show 0% reduction (progression equal to that of the spectacle-wearing controls). Two studies reported results slightly different. These studies grouped the results in terms of the percentage of subjects who had little or no progression, moderate rate of progression, and fast progression. Both studies reported similar results with 60% of OrthoK wearers categorized as “slow progressors,” 25% having “average” rate of myopia progression, and 15% “fast progressors.”36,76 This compares to spectacle wearers who showed rates of progression of 20, 60, and 20%, respectively.

TABLE 2

TABLE 2

Currently, OrthoK lenses are designed and prescribed to correct myopic refractive error and provide good unaided visual acuity. As refractive error is corrected with OrthoK, the demonstrated myopia control effect has been a beneficial side effect.77 Although OrthoK has a significant effect in slowing myopic progression, as described above, the results vary with individuals. Although some OrthoK patients show little or no myopic progression, some do continue to progress. Factors that may contribute to this variable effect include age of myopia onset, age at start of OrthoK, increasing age, degree of baseline myopia, degree of baseline astigmatism, rate of progression before initiating OrthoK, pupil size, peripheral refractive profile (before and after OrthoK), retinal topography (shape), lens design, size of resulting treatment zone, and position of the treatment zone.5,39,78–81 These studies show that better myopia control (less myopic progression) is positively associated with older age of myopia onset, older age at start of OrthoK, higher degree of baseline myopia, larger pupil size, and smaller resulting central treatment zone (more peripheral myopia induced by ring of steepening outside treatment zone). Even with these data, relative to peripheral refraction, the exact location or amount of peripheral myopic defocus that will result in the best control of myopic progression has not been determined. Future developments in peripheral refraction testing in combination with customized lens design may show even better myopia control with OrthoK.

There are studies on the effect of OrthoK on myopia progression of long duration, 7 years, and 12 years.37,81 But, most studies on myopia progression with OrthoK have been 2 to 3 years in duration. During each of these studies, refractive and axial length data have been gathered at baseline, end of the study, and at 1-year or 6-month intervals. The data in both shorter- and longer-term studies have not shown definitive trends in the slowing of myopia progression relative to the time point in the process or the duration of the process.23,37,39,41 This is due in large part to the variability factors previously mentioned.

As with other myopia control modalities, the issue of a “rebound effect” after discontinuation has been questioned. There is minimal study on this subject. One study and one case report demonstrated a return to the previous rate of myopic progression in those discontinuing OrthoK.82,83 In other words, during OrthoK, rate of myopic progression was reduced, but after discontinuation of OrthoK, the rate of myopia progression increased to its previous rate but not faster than its previous rate. One case report detailed a patient who discontinued OrthoK and stabilized at a degree of myopia less than their baseline myopia 3 years earlier.84

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SAFETY OF ORTHOKERATOLOGY

Because most OrthoK wearers are children, safety of OrthoK is a prime concern. Many years ago, there were reports of serious complications in OrthoK users in southeast Asia.83,85 Detailed analysis of these case reports showed a lack of compliance with care, limited or no regulation of fitting practices, and inappropriate lens materials or designs used. Recent studies and meta-analyses in the United States and worldwide have shown OrthoK to be very safe with very rare reports of complications.86–88 One of the largest of these investigations86 involved 58 studies in English and 112 in Chinese and summarized their findings with the following statement—“There is sufficient evidence to suggest that OrthoK is a safe option for myopia correction and retardation. Long-term success of OrthoK treatment requires a combination of proper lens fitting, rigorous compliance to lens care regimen, good adherence to routine follow-ups, and timely treatment of complications.” They also reported no long-term effect of OrthoK on corneal endothelium. In a large retrospective study of OrthoK wearers in the United States involving 1,316 patients, representing about 2,600 patient-years of wear, there were only two events of microbial keratitis (MK).87 This results in an estimated incidence of MK with OrthoK of 7.7 per 10,000 years of wear. In comparison, the incidence of MK for overnight wear of soft contact lenses was 19.5 per 10,000 wearers for conventional hydrogels and 25.4 per 10,000 wearers for silicone hydrogels. Another retrospective study on OrthoK wearers in the United States involved 296 patients during a 4.5-year period and reported three adverse events (keratitis greater than grade 2).88 Each of these events resolved without loss of best-corrected visual acuity. This study showed that OrthoK was effective in providing good vision correction with few isolated minor complications.

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PRACTICAL CONSIDERATIONS

As described earlier, controlling myopia progression has become an important public health issue. For eye care practitioners, current trends indicate that myopia control will become expected and standard of care. Orthokeratology is a safe and effective method to slow myopic progression in children. But, OrthoK is a specialized process requiring practitioners to seek specialized training, certification, and practical experience to become skilled in fitting and management of OrthoK patients. Caring for OrthoK patients is different than for traditional contact lenses. As such, office routines for OrthoK fitting, office visits, follow-ups, and lens care training must be modified to address the uniqueness of the process. In addition, to monitor myopia progression, additional testing and equipment may be required. Most importantly, corneal topography is required to fit and manage OrthoK patients. Relative to myopia progression, status may be monitored through refraction (with and without lenses on), corneal topography, and/or axial length. Studies have suggested axial length as the ultimate measure of myopic progression, but cycloplegic refraction (subjective and objective) has also been found to be effective.5

Because OrthoK lenses are worn overnight, careful, regular follow-up is critical to ensure ongoing corneal health and maintenance of clean lenses. Lens care and cleaning is not difficult, but compliance with prescribed lens care products and routines is critical to maintain a clear cornea and to minimize the potential for complications.86,88,89

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ORTHOKERATOLOGY AROUND THE WORLD

In the United States, it is estimated that there are between 500,000 and one million users of OrthoK (Personal Communication 2017—David Bland, Cary Herzberg, Rich Jeffries and Joann Simonson), whereas there may be as many as 1.5-million OrthoK wearers in China.90 Surveys show some countries with as many as 25% of GP fittings for OrthoK lenses.91 That same study also found that although most doctors believed that OrthoK was an effective method of controlling myopic progression, only a small percentage of doctors are actually prescribing OrthoK in their practice.

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SUMMARY

OrthoK allows patients to enjoy good vision without need for vision correction during their waking hours. Orthokeratology, as it is currently practiced, provides excellent vision, improves vision-related quality of life,92–95 is very safe, and is able to slow the rate of myopic progression in children. Because OrthoK gained FDA clearance (in the United States) as an option to correct refractive error, it has become more popular with eye care practitioners and with patients. As described earlier, even without specific FDA clearance to control myopic progression, most patients state that the reason they choose OrthoK is to slow increasing degree of myopia. Controlling myopic progression is of interest to eye care practitioners for reasons described earlier, and OrthoK shows a significant myopia control effect that patients readily accept and adapt to.

OrthoK is a unique field of specialty in contact lens eye care requiring practitioners to attain certification and specialty training. The process provides patients and practitioners an option to correct refractive error while slowing the rate of myopic progression. Future study may help further improve the effectiveness of OrthoK designs in slowing myopic progression.

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REFERENCES

1. Vitale S, Sperduto RD, Ferris FL III. Increased prevalence of myopia in the United States between 1971–1972 and 1999–2004. Arch Ophthalmol 2009;127:1632–1639.
2. Holden BA, Jong M, Davis S, et al. Nearly 1 billion myopes at risk of myopia-related sight-threatening conditions by 2050—Time to act now. Clin Exp Optom 2015;98:491–493.
3. Holden BA, Fricke TR, Wilson DA, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology 2016;123:1036–1042.
4. Flitcroft DI. The complex interactions of retinal, optical and environmental factors in myopia aetiology. Prog Retin Eye Res 2012;31:622–660.
5. Walline JJ, Lindsley K, Vedula SS, et al. Interventions to slow progression of myopia in children. Cochrane Database Syst Rev 2011;12:CD004916.
6. Huang J, Wen D, Wang Q, et al. Efficacy comparison of 16 interventions for myopia control in children. Ophthalmology 2016;123:697–708.
7. Wen D, Huang J, Chen H, et al. Efficacy and acceptability of orthokeratology for slowing myopic progression in children: A systematic review and meta-analysis. J Ophthalmol 2015;2015:360806.
8. Si JK, Tang K, Bi HS, et al. Orthokeratology for myopia control: A meta-analysis. Optom Vis Sci 2015;92:252–257.
9. Koffler BH, Sears JJ. Myopia control in children through refractive therapy gas permeable lenses: Is it for real? Am J Ophthal 2013;156:1076–1081.
10. Chan B, Cho P, Cheung SW. Orthokeratology practice in children in a university clinic in Hong Kong. Clin Exp Optom 2008;91:453–460.
11. Pan CW, Ramamurthy D, Saw SM. Worldwide prevalence and risk factors for myopia. Ophthal Physiol Opt 2012;32:3–16.
12. Mutti DO, Hayes JR, Mitchell JL, et al. Refractive error, axial length, and relative peripheral refractive error before and after the onset of myopia. Invest Ophthal Vis Sci 2007;48:2510–2519.
13. Cho BJ, Shin JY, Yu HG. Complications of pathologic myopia. Eye Contact Lens 2016;42:9–15.
14. Saw SM, et al. Myopia and associated pathological complications. Ophthal Physiol Opt 2005;25:381–391.
15. Mordechai S, Gradstein L, Pasanen A, et al. High myopia caused by a mutation in LEPREL1, encoding prolyl 3-hydroxylase 2. Am J Hum Genet 2011;89:438–445.
16. Read SA. Ocular and environmental factors associated with eye growth in childhood. Optom Vis Sci 2016;93:1031–1041.
17. Donovan L, Sankaridurg P, Ho A, et al. Myopia progression rates in urban children wearing single-vision spectacles. Optom Vis Sci 2012;89:27–32.
18. Rose KA, Morgan IG, Ip J, et al. Outdoor activity reduces the prevalence of myopia in children. Ophthalmology 2008;115:1279–1285.
19. Jones-Jordan LA, Sinnott LT, Cotter SA, et al. Time outdoors, visual activity, and myopia progression in juvenile-onset myopes. Invest Ophthal Vis Sci 2012;53:7169–7175.
20. Hyman L, Gwiazda J, Hussein M, et al. Relationship of age, sex, ethnicity with myopia progression and axial elongation in the correction of myopia evaluation trial. Arch Ophthalmol 2005;123:977–987.
21. Mutti DO, Sinnott LT, Mitchell GL, et al. Relative peripheral refractive error and the risk of onset and progression of myopia in children. Invest Ophthalmol Vis Sci 2011;52:199–205.
22. Jones LA, Mitchell GL, Mutti DO, et al. Comparison of ocular component growth curves among refractive error groups in children. Invest Ophthalmol Vis Sci. 2005;46:2317–2327.
23. Cho P, Cheung SW. Retardation of myopia in orthokeratology (ROMIO) study: A 2-year randomized clinical trial. Invest Ophthalmol Vis Sci 2012;53:7077–7085.
24. Freeberg DD. Letter to the editor. J Am Optom Assoc 1976;47:545.
25. Binder PS. “Orthokeratology”. In: Symposium on Medical and Surgical Diseases of the Cornea Transactions of the New Orleans Academy of Ophthalmology. St. Louis, MO, CV Mosby, 1980, pp 149–166.
26. Wesley N, Jessen G. Advanced Techniques in Contact Lens Fitting, 2nd edition. Chicago, IL, Contact Lens Publishing Company, 1960, pp 1–67.
27. Morrison RJ. Observations on contact lenses and the progression of myopia. Contacto 1958;2:20–22.
28. Stone J. The possible influence of contact lenses on myopia. Br J Physiol Opt 1976;31:89–114.
29. Jessen G. Orthofocus techniques. Contacto 1962;6:200–204.
30. Binder P, May C, Grant S. An evaluation of orthokeratology. Ophthalmology 1980;87:729–744.
31. Polse K, Brand R, Vastine D, et al. Corneal change accompanying orthokeratology. Plastic or elastic? Results of a randomized controlled clinical trial. Arch Ophthalmol 1983;101:1873–1878.
32. Wlodyga RJ, Bryla C. Corneal moulding; the easy way. Contact Lens Spectr 1989;4:14–16.
33. Mountford J, Ruston D, Dave T. Orthokeratology: Principles and practices. Ann Arbor, MI, Butterworth-Heinemann, 2004, pp 1–320.
34. El Hage S. “Photokeratoscopy and Controlled Keratoreformation”. Paper presented at the International Symposium of Ophthalmological Optics; May 7–9, 1978; Tokyo, Japan.
35. Food and Drug Administration. Summary of safety and effectiveness data of paragon CRT. Available at: http://www.accessdata.fda.gov/cdrh_docs/pdf/P870024S043b.pdf. Accessed December 13, 2017.
36. Morgan P, Woods C, Tranoudis I, et al. International contact lens prescribing in 2016. Contact Lens Spectr 2017;32:30–35.
37. Santomingo-Rubido J, Villa-Collar C, Gilmartin B, et al. Long-term efficacy of orthokeratology contact lens wear in controlling the progression of childhood myopia. Curr Eye Res 2017;42:713–720.
38. Davis RL, Eiden SB, Bennett ES, et al. Stabilizing myopia by accelerating reshaping technique (SMART)-study three year outcomes and overview. Adv Ophthalmol Vis Syst 2015;2:00046.
39. Kakita T, Hiraoka T, Oshika T. Influence of overnight orthokeratology on axial elongation in childhood myopia. Invest Ophthalmol Vis Sci 2011;52:2170–2174.
40. Sun Y, Xu F, Zhang T, et al. Orthokeratology to control myopia progression: A meta-analysis. PLoS One 2015;10:e0124535.
41. Hiraoka T, Kakita T, Okamoto F, et al. Long-term effect of overnight orthokeratology on axial length elongation in childhood myopia: A 5-year follow-up study. Invest Ophthalmol Vis Sci 2012;53:3913–3919.
42. Swarbrick HA, Wong G, O'Leary DJ. Corneal response to OrthoKeratology. Optom Vis Sci 1998;75:791–799.
43. Tsukiyama J, Miyamoto Y, Higaki S, et al. Changes in the anterior and posterior radii of the corneal curvature and anterior chamber depth by orthokeratology. Eye Contact Lens 2008;34:17–20.
44. Chen R, Mao X, Jiang J, et al. The relationship between corneal biomechanics and anterior segment parameters in the early study of orthokeratology: A pilot study. Medicine 2017;96:1–6.
45. Gifford P, Au V, Hon B, et al. Mechanism for corneal reshaping in hyperopic orthokeratology. Optom Vis Sci 2009;86:e306–e311.
46. Choo J, Caroline P, Harlin P. “How does the cornea change under corneal reshaping contact lenses?” Eye Contact Lens 2004;30:211–213.
47. Choo JD, Caroline P, Harlin P, et al. Morphologic changes in cat epithelium following continuous wear of orthokeratology lenses: A pilot study. Cont Lens Anterior Eye 2008;31:29–37.
48. Choo JD, Caroline PJ, Harline DD, et al. Morphologic changes in cat epithelium following overnight lens wear with the paragon CRT lens for corneal reshaping. Invest Ophthal Vis Sci 2004;45. E-Abstract 1552.
49. Haque S, Fonn D, Simpson T, et al. Corneal and epithelial thickness changes after 4 Weeks of overnight corneal refractive Therapy lens wear, measured with optical coherence Tomography. Eye Contact Lens 2004;30:189–193.
50. Khan GP. A prospective interventional study of effect of accelerated orthokeratology on the corneal curvature and refraction among young adults with myopia. Med J Armed Forces India 2016;72:125–130.
51. Lu F, Simpson T, Sorbara L. Malleability of the ocular surface in response to mechanical stress induced by orthokeratology contact lenses. Cornea 2008;27:133–141.
52. Sun Y, Wang L, Gao J, et al. Influence of overnight orthokeratology on corneal surface shape and optical quality. J Ophthalmol 2017;2017:3279821.
53. Swarbrick HA. Orthokeratology review and update. Clin Exp Optom 2006;89:124–143.
54. Zhong XW, Chen XL, Xie RZ, et al. Differences between overnight and long-term wear of orthokeratology contact lenses in corneal contour, thickness, and cell density. Cornea 2009;28:271–279.
55. Smith EL, Hung LF, Huang J, et al. Effects of local myopic defocus on refractive development in monkeys. Optom Vis Sci 2013;90:1176–1186.
56. Kang P, Swarbrick H. Peripheral refraction in myopic children wearing orthokeratology and gas-permeable lenses. Optom Vis Sci 2011;88:476–482.
57. Lin Z, Martinez A, Chen X, et al. Peripheral defocus with single-vision spectacle lenses in myopic children. Optom Vis Sci 2010;87:4–9.
58. Charman WN, Mountford J, Atchison DA, et al. Peripheral refraction in orthokeratology patients. Optom Vis Sci 2006;83:641–648.
59. Queirós A, Gonzalez-Meijome JM, Jorge J, et al. Peripheral refraction in myopic patients after orthokeratology. Optom Vis Sci 2010;87:323–329.
60. Rotolo M, Montani G, Martin R. Myopia onset and role of peripheral refraction. Clin Optom 2017;9:105–111.
61. Smith EL, Kee CS, Ramamirtham R, et al. Peripheral vision can influence eye growth and refractive development in infant monkeys. Invest Ophthalmol Vis Sci 2005;46:3965–3972.
62. Benavente-Perez A, Nour A, Troilo D. Axial eye growth and refractive error development can Be modified by exposing the peripheral retina to relative myopic or hyperopic defocus. Invest Ophthalmol Vis Sci 2014;55:6765–6773.
63. Smith EL, Charles F. Prentice award lecture 2010: A case for peripheral optical treatment strategies for myopia. Optom Vis Sci 2011;88:1029–1044.
64. Hiraoka T, Okamoto C, Ishii Y, et al. Contrast sensitivity function and ocular higher-order aberrations following overnight orthokeratology. Invest Ophthalmol Vis Sci 2007;48:550–556.
65. Joslin CE, Wu SM, McMahon TT, et al. Higher-order wavefront aberrations in corneal refractive therapy. Optom Vis Sci 2003;80:805–811.
66. Tarrant J, Liu Y, Wildsoet CF. Orthokeratology can decrease the accommodative lag in myopes. Invest Opthamal Vis Sci 2009;50:4294.
67. Berntsen DA, Sinnott LT, Mutti DO, et al. Accommodative lag and juvenile-onset myopia progression in children wearing refractive correction. Vis Res 2011;51:1039–1046.
68. Read SA, Collins MJ, Vincent SJ, et al. Choroidal thickness in childhood. Invest Ophthalmol Vis Sci 2013;54:3586–3593.
69. Summers JA. The choroid as a sclera growth regulator. Exp Eye Res 2013;114:120–127.
70. Chiang ST, Phillips JR, Backhouse S. Effect of retinal image defocus on the thickness of the human choroid. Ophthalmic Physiol Opt 2015;35:405–413.
71. Chen Z, Xue F, Zhou J, et al. Effects of orthokeratology on choroidal thickness and axial length. Optom Vis Sci 2016;93:1064–1071.
72. Cho P, Cheung SW, Edwards M, et al. The longitudinal orthokeratology research in children (LORIC) in Hong Kong: A pilot study on refractive changes and myopic control. Curr Eye Res 2005;30:71–80.
73. Walline JJ, Jones LA, Sinnott LT, et al. Corneal reshaping and myopia progression. Br J Ophthalmol 2009;93:1181–1185.
74. Santodomingo-Rubido J, Villa-Collar C, Gilmartin B, et al. Myopia control with orthokeratology contact lenses in Spain: Refractive and biometric changes. Invest Ophthalmol Vis Sci 2012;53:5060–5065.
75. Charm J, Cho P. High myopia partial reduction ortho-k: A 2-year randomized study. Optom Vis Sci 2013;90:530–539.
76. Lipson MJ, Harris JK, Lather HD, et al. Axial length in orthokeratology patients: Large case series. Adv Ophthalmol Vis Syst 2016;5:00154.
77. Lipson MJ, Sandall G. Myopia Control: Science or luck. Eye Contact Lens 2016;42:80–81.
78. Wang B, Naidu RK, Qu X. Factors related to axial length elongation and myopia progression in orthokeratology practice. PLoS One 2017;12: e0175913.
79. Zhong Y, Chen Z, Xue F, et al. Corneal power change is predictive of myopia progression in orthokeratology. Optom Vis Sci 2014;91:404–411.
80. Chen Z, Niu L, Xue F, et al. Impact of pupil diameter on axial growth in orthokeratology. Optom Vis Sci 2012;89:1636–1640.
81. Lee YC, Wang JH, Chiu CJ. Effect of orthokeratology on myopia progression: Twelve-year results of a retrospective cohort study. BMC Ophthalmol 2017;17:243.
82. Lee TT, Cho P. Discontinuation of orthokeratology and myopic progression. Optom Vis Sci 2010;87:1053–1056.
83. Cho P, Cheung SW. Discontinuation of orthokeratology on eyeball elongation (DOEE). Cont Lens Anterior Eye 2017;40:82–87.
84. Lee TT, Cho P. Rebound of refractive errors after discontinuation of orthokeratology treatment—A case report. Cont Lens Anterior Eye 2013;36:e18–e19.
85. Watt KG, Swarbrick HA. Trends in microbial keratitis associated with orthokeratology. Eye Contact Lens 2007;33:373–377; 382.
86. Liu YM, Xie P. The safety of orthokeratology—A systematic review. Eye Contact Lens 2016;42:35–42.
87. Bullimore M, Sinott LT, Jones-Jordan LA. The incidence of microbial keratitis with overnight corneal reshaping lenses. Optom Vis Sci 2013;90:937–944.
88. Lipson MJ. Long-term clinical outcomes for overnight corneal reshaping in children and adults. Eye Contact Lens 2008;34:94–99.
89. Lo J, Kuo MT, Chien CC, et al. Microbial bioburden of orthokeratology contact lens care system. Eye Contact Lens 2016;42:61–67.
90. Xie P, Guo X. Chinese experiences on orthokeratology. Eye Contact Lens 2016;42:43–47.
91. Wolffsohn JS, Calossi A, Cho P, et al. Global trends in myopia management attitudes and strategies in clinical practice. Cont Lens Anterior Eye 2016;39:106–116.
92. Lipson MJ, Sugar A, Musch DC. Overnight corneal reshaping versus soft disposable contact lenses: Vision-related quality-of-life differences from a randomized clinical trial. Optom Vis Sci 2005;82:886–891.
93. Hiraoka T, Okamoto C, Ishii Y, et al. Patient satisfaction and clinical outcomes after overnight orthokeratology. Optom Vis Sci 2009;86:875–882.
94. Queiros A, Villa-Collar C, Gutiérrez AR, et al. Quality of life of myopic subjects with different methods of visual correction using the NEI RQL-42 questionnaire. Eye Contact Lens 2012;38:116–121.
95. Santodomingo-Rubido J, Villa-Collar C, Gilmartin B, et al. Myopia control with orthokeratology contact lenses in Spain: A comparison of vision-related quality-of-life measures between orthokeratology contact lenses and single-vision spectacles. Eye Contact Lens 2013;39:153–157.
Keywords:

Orthokeratology; Myopia progression; Myopia management; Myopia control

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