Antimicrobial agents are being examined with the aim of developing antimicrobial contact lenses and new forms of antimicrobial lens cases. It is hoped that these developments will result in reduced contact lens-related microbial adverse events. In this review, we assess aspects of various antimicrobial strategies, such as cationic metals and peptides, selenium, quorum sensing inhibitors, and various biocidal and non-cidal agents. We highlight the historical challenges, the current scenario of this field, and recommendations for future antimicrobial strategies.
School of Optometry and Vision Science (D.D., M.D.P.W.), The University of New South Wales, Sydney, New South Wales, Australia; and Brien Holden Vision Institute (D.D.), Sydney, New South Wales, Australia.
Address correspondence to Debarun Dutta, Ph.D., School of Optometry and Vision Science, Rupert Myers Building, Gate 14, Barker Street, The University of New South Wales, Sydney, New South Wales 2052, Australia; e-mail: firstname.lastname@example.org
Supported by a University International Postgraduate Award (to D.D.), The University of New South Wales, Optometric Vision Research Foundation Maki Shiobara scholarship, Ezell fellowship from American Academy of Optometry and the Brien Holden Vision Institute.
The authors have no conflicts of interest to disclose.
Accepted May 21, 2014