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Treatment Limitations With PROSE (Prosthetic Replacement of the Ocular Surface Ecosystem)

One Centers Experience

Schear, Matthew J. D.O.; Ibrahim, Kirolos M.D.; Winokur, Jules M.D.; Busuioc, Corina O.D.; Udell, Ira M.D.; Steiner, Anne M.D.

doi: 10.1097/ICL.0000000000000610
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Objectives: The prosthetic replacement of the ocular surface ecosystem (PROSE) device is used to treat difficult-to-manage ocular surface disease (OSD) and ectasia. Previous studies have demonstrated positive treatment outcomes. This study aims to document treatment failures to better tailor treatment and address limitations with its use.

Methods: Retrospective chart review of consecutive PROSE fits performed at Northwell Health from 2012 to 2016. Reasons for patient discontinuation of treatment were documented, and potential risk factors for treatment failure were assessed.

Results: The total number of eyes treated was 125. Fifty five eyes had ectasia, 67 had OSD, and 3 had both ectasia and OSD. A total of 8/125 (6.4%) of eyes failed treatment; 6/8 (75%) of failed treatments had worsening corneal edema, all of which had presumed risk factors for lower endothelial cell counts. Two eyes discontinued use secondary to intractable debris on the device, blurring vision. The most common diseases in patients failing therapy in descending order included: keratoconus and Fuch's dystrophy, ectasia after penetrating keratoplasty, and graft versus host disease. Those with presumed risks factors for lower endothelial cell counts (Fuch's dystrophy and patients with previous penetrating keratoplasty) were more likely to fail (22.2%) compared with those without a risk of a low endothelial cell count (1.6%).

Conclusion: Although PROSE use has high success, corneal edema secondary to endothelial dysfunction is a potential limitation that may lead to treatment failure. Patients with lower endothelial cell counts after penetrating keratoplasty or with Fuch's dystrophy were more likely to fail treatment.

Department of Ophthalmology (M.J.S., J.W., C.B., I.U., A.S.), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, NY; and Stony Brook University School of Medicine (K.I.).

Address correspondence to Anne Steiner, M.D., Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 600 Northern Boulevard, Suite 218, New York 11021, NY; e-mail: Asteiner1@northwell.edu

The authors have no funding or conflicts of interest to disclose.

Accepted March 02, 2019

© 2019 Contact Lens Association of Ophthalmologists, Inc.