Case Report: PDF OnlyBilateral EK Rejection After COVID-19 VaccineAbousy, Mya B.A.; Bohm, Kelley M.D.; Prescott, Christina M.D., Ph.D.; Bonsack, Jeanette M. O.D; Rowhani-Farid, Anisa Ph.D.; Eghrari, Allen O. M.D., M.P.H.Author Information Wilmer Eye Institute (M.A., K.B., C.P., J.M.B., A.O.E.), Johns Hopkins University School of Medicine, Baltimore, MD; and Department of Pharmaceutical Health Services Research (A.R.-F.), University of Maryland School of Pharmacy, Baltimore, MD. Address correspondence to Allen O. Eghrari, M.D., M.P.H., Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21287; e-mail: [email protected] The authors have no funding or conflicts of interest to disclose. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.eyeandcontactlensjournal.com). Accepted August 13, 2021 Eye & Contact Lens: Science & Clinical Practice: September 8, 2021 - Volume - Issue - doi: 10.1097/ICL.0000000000000840 Buy SDC PAP Metrics Abstract Owing to its rapid development, short-term and long-term effects of the COVID-19 vaccine are still not well understood. This case report highlights bilateral corneal endothelial graft rejection after administration of the Pfizer COVID-19 vaccine. A 73-year-old woman with bilateral Descemet stripping endothelial keratoplasty presented with bilateral decreased visual acuity, ocular pain, and photophobia after her second dose of the Pfizer-BioNTech COVID-19 vaccine. Two weeks after vaccine administration, the uncorrected visual acuity was 20/70 and 20/40. Central corneal thickness as measured by ultrasound was 809 and 825 μm and by Scheimfplug imaging was 788 and 751 μm at the pupil center. Slit-lamp biomicroscopy revealed quiet conjunctiva and sclera but was significant for thickened corneas with Descemet folds in both eyes. The patient was instructed to use prednisolone acetate 1% every 1 to 2 hours with Muro ointment at bedtime. © 2021 Contact Lens Association of Ophthalmologists, Inc.