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Predictability of the Achieved Lenticule Thickness in Small Incision Lenticule Extraction for Myopia Correction

Zhou, Jiaqi, M.D., Ph.D.; Zhang, Yan, M.D., Ph.D.; Li, Meiyan, M.D., Ph.D.; Sun, Ling, M.D., Ph.D.; Zhou, Xingtao, M.D., Ph.D.

doi: 10.1097/ICL.0000000000000504

Purpose: To investigate the predictability of the achieved lenticule thickness in small incision lenticule extraction (SMILE) for the correction of myopia.

Methods: In this prospective study, a total of 80 eyes of 45 patients who underwent the SMILE procedure were included. A Scheimpflug camera was used to measure the preoperative and postoperative corneal topography. Achieved lenticule thicknesses at the pupil center and corneal vertex were calculated by subtracting the postoperative corneal thickness at the pupil center and corneal vertex from preoperative corresponding values. Predictability between the achieved and VisuMax readout at different locations (the pupil center and corneal vertex) and postoperative visits (postoperative day 1 and 6 months) were evaluated using a general linear model.

Results: Achieved lenticule thickness at the pupil center and corneal vertex showed good correlation at both postoperative day 1 (pupil center: r=0.914, corneal vertex: r=0.903) and 6 months (pupil center: r=0.886, corneal vertex: r=0.866). The achieved lenticule thickness at postoperative day 1 was 8.5-μm thinner at the pupil center and 9.6-μm thinner at the corneal vertex than the VisuMax readout.

Conclusions: This study suggests that the predictability between the achieved and VisuMax readout is favorable. The lenticule thickness at the pupil center is closer to the VisuMax readout than corneal vertex.

Department of Ophthalmology (J.Z., M.L., L.S., X.Z.), Key Lab of Myopia, Ministry of Health, EYE & ENT Hospital of Fudan University, Shanghai, China; and Department of Ophthalmology (Y.Z.), Second Hospital of Jilin University, Changchun, China.

Address correspondence to Xingtao Zhou, M.D., Ph.D., Department of Ophthalmology, EYE & ENT Hospital of Fudan University, 19 Baoqing Road, Shanghai, China 200031; e-mail:

The authors have no funding or conflicts of interest to disclose.

Supported by Natural Science Foundation of China (Grant No. 81500753); Natural Science Foundation of China (Grant No. 81570879).

Concept and design (M.L. and X.Z.); analysis and interpretation (J.Z., Y.Z., M.L., and X.Z.); writing the article (J.Z., Y.Z., and M.L.); critical revision of the article (J.Z. and X.Z.); final approval of the article (J.Z., Y.Z., M.L., L.S., and X.Z.); data collection (J.Z., Y.Z., and L.S.); provision of materials, patients, or resources (X.Z.); statistical expertise (M.L. and L.S.); literature research (J.Z., M.L., and Y.Z.); and administrative, technical, or logistic support (X.Z.). All authors have reviewed the manuscript.

J. Zhou and Y. Zhang contributed equally to this work and were considered co-first authors.

Availability of data and materials: Available on request from the co-first authors J. Zhou and Y. Zhang.

Accepted February 20, 2018

© 2018 Contact Lens Association of Ophthalmologists, Inc.