Review ArticleOcular Graft-Versus-Host Disease A ReviewBalasubramaniam, Saranya C. M.D.; Raja, Harish M.D.; Nau, Cherie B. O.D.; Shen, Joanne F. M.D.; Schornack, Muriel M. O.D.Author Information Department of Ophthalmology (S.C.B., H.R., C.B.N., M.M.S.), Mayo Clinic, Rochester, MN; and Department of Ophthalmology (J.F.S.), Mayo Clinic, Scottsdale, AZ. Address correspondence to Muriel M. Schornack, O.D., Department of Ophthalmology, Mayo Clinic, 200 First St SW, Rochester, MN 55905; e-mail: [email protected] The authors have no funding or conflicts of interest to disclose. Accepted February 03, 2015 Eye & Contact Lens: Science & Clinical Practice: September 2015 - Volume 41 - Issue 5 - p 256-261 doi: 10.1097/ICL.0000000000000150 Buy Metrics Abstract Hematopoietic stem cell transplantation is important in the management of several lymphoproliferative and bone marrow disorders. Graft-versus-host disease (GVHD) involves inflammatory manifestations that arise after transplant and can affect many organs. Ocular manifestations of GVHD are common, and eye care providers must understand this disease entity. The ocular surface is most commonly involved, but GVHD can affect all parts of the eye. Ocular GVHD can be relapsing and remitting, can decrease quality of life, and can be challenging to diagnose and adequately treat. The diagnostic criteria for and grading of ocular GVHD continue to evolve. This review aims to summarize current definitions, clinical findings, diagnostic criteria, and management of ocular GVHD. The care of patients with ocular GVHD requires a multidisciplinary approach. © 2015 Contact Lens Association of Ophthalmologists, Inc.