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Autologous Serum Eye Drops for the Treatment of Ocular Surface Disease

Azari, Amir A. M.D.; Rapuano, Christopher J. M.D.

Eye & Contact Lens: Science & Clinical Practice: May 2015 - Volume 41 - Issue 3 - p 133–140
doi: 10.1097/ICL.0000000000000104
Review Article

Objective: To examine the evidence for the role of autologous serum eye drops (ASD) in disease of the ocular surface.

Methods: A search of the literature published through May 2014 using PubMed, the ISI Web of Knowledge database, and the Cochrane Library was performed. Qualified articles were selected after review of titles, abstracts, and references.

Results: There was a significant improvement in either symptoms or some of the clinical examination findings, including tear breakup time, corneal staining, Schirmer values, and impression cytology in eyes with persistent corneal epithelial defect, graft-versus-host disease, Sjögren- and non–Sjögren-related dry eye disease, limbal stem-cell deficiency, recurrent corneal erosion, superior limbic keratoconjunctivitis, and postrefractive surgery. However, most of the studies were nonrandomized in nature.

Conclusions: Despite the paucity of strong supporting evidence from randomized double-masked clinical studies, there seems to be a trend toward superiority of ASD in alleviating some of the clinical signs and symptoms associated with corneal pathology in a variety of conditions that affect the ocular surface compared with conventional lubricating drops/ointments.

Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA.

Address correspondence to Amir A. Azari, M.D., Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, 840 Walnut Street, Suite 920, Philadelphia, PA 19107; e-mail:

The authors have no funding or conflicts of interest to disclose.

Accepted September 15, 2014

© 2015 Contact Lens Association of Ophthalmologists, Inc.