Institutional members access full text with Ovid®

Share this article on:

Systane® Ultra Lubricant Eye Drops for Treatment of Contact Lens–Related Dryness

McDonald, Marguerite M.D.; Schachet, John L. O.D.; Lievens, Christopher W. O.D., M.S.; Kern, Jami R. M.B.A., Ph.D.

doi: 10.1097/ICL.0000000000000018

Objectives: To assess the clinical performance of Systane® Ultra lubricant eye drops in daily disposable soft contact lens wearers who experience contact lens–related dryness.

Methods: In this randomized, investigator-masked study, daily disposable lens wearers with symptoms of dryness were randomized to use Systane Ultra lubricant eye drops or to no treatment. The lubricant regimen was applied twice a day, 10 minutes before lens insertion and after lens removal, for the 2-week study period. Subjective comfort, wear time, and visual acuity were assessed at baseline and after 2 weeks.

Results: A total of 89 daily disposable lens wearers were randomly assigned to the Systane Ultra group (n=44) or the control group (n=45). Two weeks of Systane Ultra lubricant eye drop use resulted in a significant increase in comfortable lens wear time when compared with baseline assessment (P=0.001) and a trend toward significant improvement compared with the control group (P=0.078). End-of-the-day comfort was significantly improved in the Systane Ultra group compared with the control group (P=0.007). A significant reduction in the overall dryness (P<0.001) and end-of-day dryness (P=0.047) was observed in subjects using the Systane Ultra lubricant eye drops compared with the control group.

Conclusion: The study demonstrates that Systane Ultra lubricant eye drops applied before and after contact lens wear is an effective artificial tear for alleviating symptoms of contact lens–related dry eye.

Ophthalmic Consultants of Long Island (M.M.), Lynbrook, NY; EyeCare Consultants (J.L.S.), Englewood, CO; The Eye Center (C.W.L.), Southern College of Optometry, Memphis, TN; and Alcon Research Ltd., Global Medical Affairs (J.R.K.), Fort Worth, TX.

Address correspondence to Marguerite McDonald, M.D., Ophthalmic Consultants of Long Island, 360 Merrick Road, Lynbrook, NY 11563; e-mail:

Supported by Alcon Research Ltd., Fort Worth, TX.

M. McDonald is a consultant to Alcon. J. L. Schachet and C. W. Lievens are on the speaker's bureau for Alcon. J. R. Kern is an employee of Alcon, Fort Worth, TX.

Accepted December 16, 2013

© 2014 Contact Lens Association of Ophthalmologists, Inc.