Institutional members access full text with Ovid®

Share this article on:

Short-Term Clinical Comparison of Two Dual-Disinfection Multipurpose Disinfecting Solutions

Tilia, Daniel M.Optom.; Lazon de la Jara, Percy Ph.D.; Weng, Rebecca B.Optom.; Naduvilath, Thomas Ph.D.; Willcox, Mark D.P. Ph.D.

doi: 10.1097/01.ICL.0000436270.08502.d3

Objective: To compare the short-term clinical performance of two dual-disinfectant multipurpose disinfecting solutions (MPDS) when used in conjunction with two silicone hydrogel contact lenses.

Methods: Participants wore galyfilcon A and balafilcon A lenses, randomly allocated one type to each eye. Multipurpose disinfecting solutions were double-masked and allocated using a randomized crossover design. Lenses were presoaked overnight in the allocated MPDS, containing either polyquaternium-1/alexidine dihydrochloride (PQ-alexidine) or polyquaternium-1/myristamidopropyl dimethylamine (PQ-MAPDA). Lenses were worn daily for 4 days and disinfected with the same MPDS in which they had been soaked. Clinical assessments occurred immediately after insertion, 2 hours after insertion, and after 2 hours of wear on day 4. Subjective ratings were collected at each assessment and after 6 hours of wear on days 1 to 3. Linear mixed models were used for statistical analysis.

Results: Solution-induced corneal staining (SICS) incidence was significantly different between MPDS lens combinations (P=0.01) with PQ-MAPDA-balafilcon A showing the highest incidence (27.8%). The incidence of SICS was significantly higher when balafilcon A lenses were worn compared with galyfilcon A (19.4% vs. 2.8%; P=0.04). There was no significant difference in SICS incidence between MPDS (PQ-alexidine=5.6%, PQ-MAPDA=16.7%; P=0.08). Polyquaternium-1/alexidine dihydrochloride was associated with significantly fewer symptoms of burning/stinging (9.7±0.6 vs. 9.1±2.2; P=0.03) and self-assessed redness (9.8±0.5 vs. 9.2±1.9; P=0.03) on initial lens insertion. There were no significant differences between MPDS for comfort ratings (P>0.05).

Conclusion: These short-term clinical results provide an initial indication that PQ-alexidine is associated with fewer symptoms on insertion but no significant difference in ocular comfort compared with PQ-MAPDA. Longer studies are required to provide further evidence.

Brien Holden Vision Institute (D.T., P.L.d.l.J., R.W., T.N.), Sydney, New South Wales, Australia; and

School of Optometry and Vision Science (P.L.d.l.J., M.D.P.W.), University of New South Wales, Sydney, New South Wales, Australia.

Address correspondence to Daniel Tilia, M.Optom., Brien Holden Vision Institute, Level 5, Rupert Myers Building, North Wing, University of New South Wales, Sydney, New South Wales 2052, Australia; e-mail:

This study was sponsored by Abbott Medical Optics, Inc and in kind by the Brien Holden Vision Institute.

Accepted July 29, 2013

© 2014 Contact Lens Association of Ophthalmologists, Inc.