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Management of Bullous Keratopathy-Related Ulcer With Autologous Serum

Mataftsi, Asimina M.D., Ph.D., M.R.C.Ophth.; Bourtoulamaiou, Areti M.D.; Anastasilakis, Konstantinos M.D.; Ziakas, Nikolaos G. M.D., Ph.D.; Dimitrakos, Stavros A. M.D., Ph.D.

doi: 10.1097/ICL.0b013e31825f6386
Case Report

Purpose: The aim of this study was to report the use of autologous serum eyedrops (ASEs) for resolution of a corneal ulcer secondary to bullous keratopathy.

Methods: This is a case report.

Results: A 66-year-old patient presented with an infected ulcer and hypopyon while using a bandage contact lens for bullous keratopathy. Staphylococcus warneri infection was treated with systemic and topical antibiotics, and ASEs were subsequently administered to enhance reepithelialization and to avoid the need for a bandage contact lens. The ASE treatment led to closure of the epithelium layer within 3 weeks, and it was subsequently tapered over the next 3 months. The clinical picture remained stable subjectively and objectively during the 7 months of follow-up.

Discussion: To the best of our knowledge, this is the first report of successful use of ASEs in treating and preventing recurrence of ulcers in the context of bullous keratopathy.

IInd Department of Ophthalmology (A.M., A.B., K.A., S.A.D.), Aristotle University of Thessaloniki, Thessaloniki, Greece; Ist Department of Ophthalmology (N.G.Z.), Aristotle University of Thessaloniki, Thessaloniki, Greece.

Address correspondence and reprint requests to Asimina Mataftsi, M.D., M.R.C.Ophth., IInd Department of Ophthalmology, Aristotle University of Thessaloniki, General Hospital of “Papageorgiou,” Periferiaki Odos Thessalonikis, N. Efkarpia 56403, Thessaloniki, Greece; e-mail:

The author has no funding or conflicts of interest to disclose.

Accepted May 14, 2012

© 2013 Contact Lens Association of Ophthalmologists, Inc.