Review ArticleBiocompatibility in the Development of Silicone-Hydrogel LensesJacob, Jean T. Ph.D.Author Information Department of Ophthalmology (J.T.J.), Louisiana State University Health Science Center, School of Medicine, New Orleans, LA. Address correspondence and reprint requests to Jean T. Jacob, Ph.D., Department of Ophthalmology, School of Medicine, LSU Eye Center, LSUHSC SOM, 2020 Gravier St Suite B, New Orleans, LA 70112; e-mail: email@example.com Supported in part by Alcon Labs, Fort Worth, TX; Contact Lens Association of Ophthalmologists, St. Louis, MO; Louisiana Lions Eye Foundation, New Orleans, LA; Research to Prevent Blindness, New York, NY. The author has no funding or conflicts of interest to disclose. Accepted November 12, 2012 Eye & Contact Lens: Science & Clinical Practice: January 2013 - Volume 39 - Issue 1 - p 13-19 doi: 10.1097/ICL.0b013e31827dbb00 Buy Metrics Abstract Abstract: In response to patient demands for extended contact lens wearing times, the contact lens industry has developed novel silicone-hydrogel (SiHy) lens materials that combine the enhanced oxygen permeability of silicone polymers with the water-based comfort of conventional hydrogels. In the past 12 years since the successful launch of these SiHy lenses, much has been learned about their ability to provide the biocompatibility necessary to sustain ocular health and comfort. A review of the unique physiologic requirements for a successful extended wear lens and how the first and current SiHy lenses address them is provided. © 2013 Lippincott Williams & Wilkins, Inc.