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Corneal Melanoma: Report of Three Cases

Uçakhan-Gündüz, Ömür M.D.; Gündüz, Kaan M.D.; Karslioğlu, Melisa Z. M.D.; Okçu-Heper, Aylin M.D.; Kanpolat, Ayfer M.D.

doi: 10.1097/ICL.0b013e318237d195
Case Report

Objectives: We report three cases of corneal melanoma: two without conjunctival primary acquired melanosis or melanoma and one with a history of conjunctival melanoma.

Methods: Report of 3 cases with corneal melanoma and literature review.

Results: Medical records of three patients with the diagnosis of corneal melanoma were reviewed. Total excisional biopsy with corneal epitheliectomy using 20% ethanol was performed. Postoperative topical chemotherapy with 0.04% mitomycin-C was used for 4 weeks as adjunctive therapy. The follow-up ranged from 13 months to 7 years. Each of the two patients experienced two recurrences. One was treated in a fashion similar to that of the initial tumor, and the other was treated by enucleation. None of the patients developed regional or distant metastasis.

Conclusions: Malignant melanoma can rarely occur on the cornea with no contiguous conjunctival component. Eye-conserving treatment should be attempted first. Recurrences may occur, and a close follow-up is necessary.

Department of Ophthalmology (Ö.U.G., K.G., A.K., M.Z.K.), Ankara University Faculty of Medicine, Ankara, Turkey; Department and Department of Pathology (A.O-H.), Ankara University Faculty of Medicine, Ankara, Turkey.

Address correspondence and reprint requests to Ömür Uçakhan-Gündüz, M.D., Mesa Koza Plaza, Kupe Sokak 24/18, Blok 3, GOP 06700, Ankara, Turkey; e-mail:

Supported in part by a grant from the Ankara University.

The authors have no funding or conflicts of interest to disclose.

Accepted September 14, 2011

© 2012 Contact Lens Association of Ophthalmologists, Inc.