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A Case of Sympathetic Ophthalmia After a Severe Acanthamoeba Keratitis

Guerriero, Silvana M.D.; Montepara, Alfonso M.D.; Ciracì, Lorenza M.D.; Monno, Rosa B.Sc.; Cinquepalmi, Vittoria B.Sc.; Vetrugno, Michele M.D.

doi: 10.1097/ICL.0b013e3182128e93
Case Report

Purpose: To report a case of sympathetic ophthalmia (SO) after a severe Acanthamoeba keratitis.

Methods/Design: Interventional case report.

Results: A 59-year-old white woman, wearing contact lenses, developed a severe Acanthamoeba keratitis in the left eye, which involved the limbus, and required 8 months of intensive antiamoeba therapy; the condition resolved leaving a painful, phthisical eye with complete corneal neovascularization. Six months later, the patient presented with pain, blurred vision, and photophobia in the right eye. Slitlamp examination of the right eye revealed granulomatous uveitis. On the suspicion of an SO, treatment with high-dose topical and oral corticosteroids and immunosuppressants was started. After 3 months, the eye is stable, with a visual acuity of 20/50, and the patient is taking prednisolone 7.5 mg per day and cyclophosphamide 50 mg per day.

Conculsions: Development of SO in the absence of previous trauma or surgery is rare. Our case is the first report of a clinically diagnosed SO after an episode of severe Acanthamoeba keratitis.

From the Department of Ophthalmology and Otolaryngology (S.G., A.M., L.C., M.V.), Bari University, Italy; and Department of Odontostomatology and Surgery (R.M., V.C.) Bari University, Bari, Italy.

None of the authors have a financial or proprietary interest in any material or method mentioned.

Address correspondence and reprint requests to Silvana Guerriero, M.D., Department of Ophthalmology, Bari University, Piazza Giulio Cesare 11, Bari 70124, Italy; e-mail:

Accepted January 26, 2011.

© 2011 Lippincott Williams & Wilkins, Inc.