Review ArticleCorneal Staining as a Response to Contact Lens WearFonn, Desmond Dip.Optom., M.Optom.; Peterson, Rachael Ph.D.; Woods, Craig Ph.D.Author Information From the Centre for Contact Lens Research, School of Optometry, University of Waterloo, ON, Canada. The authors have no funding or conflicts of interest to disclose. Address correspondence and reprint requests to D. Fonn, Centre for Contact Lens Research, School of Optometry, University of Waterloo, Ontario, Canada; e-mail: [email protected] Accepted July 22, 2010. Eye & Contact Lens: Science & Clinical Practice: September 2010 - Volume 36 - Issue 5 - p 318-321 doi: 10.1097/ICL.0b013e3181f35d54 Buy Metrics Abstract Objective: To review the effects of contact lenses on the corneal surface. Methods: A review of the literature and in-house research of corneal staining and its various forms of presentation. Results: Corneal staining manifests in many different forms. The severity of staining or insult of the cornea is usually determined by the extent (area of coverage), density, and depth. The cause of staining is multifactorial, and its location is often linked to the type of lens that is being worn, the solution used to clean/disinfect the lens, the state of hydration of the soft lens, and the state of the cornea that has been affected by the lens. Conclusions: Sodium fluorescein dye effectively highlights corneal integrity changes referred to as corneal staining. This review describes the manifestations, the cause, the mechanisms, and the methods of remediation of corneal staining. © 2010 Lippincott Williams & Wilkins, Inc.