ArticlesComparison of the Effects of Dorzolamide–Timolol Fixed Combination and Brimonidine on Intraocular Pressure After Phacoemulsification SurgeryOzkurt, Yelda M.D.; Oral, Yesim M.D.; Karacan, Ozgul M.D.; Comez, Arzu M.D.; Dogan, Omer K. M.D.Author Information From PTT Hospital (Y.O.), and Kartal Training and Research Hospital, First Eye Clinic (Y.O., O.K., A.C., O.D.), Istanbul, Turkey. Address correspondence and reprint requests to Dr. Y. Ozkurt, PTT Hospital, Korkut. Sok. Dumankaya Evleri A1 B Blok Sen Apt 917 Kozyatagi-Istanbul, Turkey. Accepted March 7, 2007. Eye & Contact Lens: Science & Clinical Practice: January 2008 - Volume 34 - Issue 1 - p 21-23 doi: 10.1097/ICL.0b013e3180587e0a Buy Metrics Abstract Purpose. To compare the effects of dorzolamide–timolol combination and brimonidine on intraocular pressure (IOP) after phacoemulsification surgery. Methods. This prospective, randomized study included 69 eyes of 43 patients undergoing phacoemulsification and foldable intraocular lens implantation. Twenty-one patients were women and 22 were men. The mean patient age was 69.7 ± 12.4 years. Patients were randomly assigned to one of three treatment groups preoperatively. Group A (n = 23) received one drop of dorzolamide–timolol fixed combination and group B (n = 23) received one drop of brimonidine tartrate 0.2% immediately after surgery. In group C (n = 23), patients received no treatment and served as a control group. IOP was measured by Goldmann applanation tonometry 6 hours and 24 hours after surgery. Results. Six hours after surgery, the mean IOP was significantly lower in group A (16.3 ± 2.9 mm Hg) than in groups B (20.6 ± 2.9 mm Hg) and C (24.6 ± 5.4 mm Hg). However, 24 hours after surgery, the mean IOP was higher in group C (19.8 ± 4.7 mm Hg) than in the other two groups (14.1 ± 2.8 mm Hg in group A and 17.5 ± 2.7 mm Hg in group B). Conclusions. Prophylactic treatment with dorzolamide–timolol fixed combination was more effective than brimonidine in reducing IOP 6 hours and 24 hours after phacoemulsification surgery. © 2008 Lippincott Williams & Wilkins, Inc.