ArticlesAn Early Assessment of Silicone Hydrogel Safety: Pearls and Pitfalls, and Current StatusKeay, Lisa Ph.D.; Edwards, Katie B.App.Sc. (Optom.); Stapleton, Fiona Ph.D.Author Information From the School of Optometry and Vision Science (L.K., K.E., F.S.), University of New South Wales, Sydney, Australia; Vision CRC (L.K., K.E., F.S.), Sydney, Australia; and the Institute for Eye Research (F.S.), Sydney, Australia. Address correspondence and reprint requests to Dr. L. Keay, 116 Wilmer Building, 600 North Wolfe Street, Baltimore, MD 21287-9019; e-mail: [email protected] Accepted August 1, 2007. Eye & Contact Lens: Science & Clinical Practice: November 2007 - Volume 33 - Issue 6 Part 2 of 2 - p 358-361 doi: 10.1097/ICL.0b013e318157c77f Buy Metrics Abstract The contact lens industry has evolved and now provides many choices, including continuous wear, overnight orthokeratology, frequent-replacement lenses, daily-disposable lenses, and many alternatives in systems of care and maintenance. Epidemiologic studies to date have shown that how a lens is worn, particularly if worn overnight, can increase the risk of microbial keratitis. However, the risk of silicone hydrogel contact lenses worn on a continuous-wear basis has been evaluated only recently. This article summarizes the recent research data on extended-wear silicone hydrogel lenses and discusses the challenges of early evaluations of silicone hydrogel lens safety. Finally, the relevance of this information is discussed to practitioners and contact lens wearers making choices about the risks and benefits of different products and how they are used. © 2007 Lippincott Williams & Wilkins, Inc.