ARTICLESClinical Results Comparing High-Oxygen and Low-Oxygen Permeable Soft Contact Lenses In FranceMalet, Florence M.D.; Pagot, Roland M.D.; Peyre, Catherine M.D.; Subirana, Xavier M.D.; Lejeune, Sophie M.D.; George-Vicariot, Marie-Noëlle M.D.; Bleshoy, Hans Ph.D.; Long, Bill B.S., F.A.A.O.Author Information From the Hopital Pelegrin, Bordeaux, France (F.M); La Maison Rouge, Strasbourg, France (R.P); Private practice, Paris, France (C.P.); Private practice, Toulouse, France (X.S.); Private practice, Lyon, France (S.L.); Private practice, Coueron, France (M-N. G-V.); Danish Contact Lens Consultants, Skive, Denmark (H.B.); and CIBA Vision Corporation, Duluth, GA (B.L.). Accepted June 19, 2002. Address correspondence to: Bill Long, B.S., F.A.A.O., CIBA Vision Corp., 11460 John’s Creek Parkway, Duluth, GA 30097. Phone: (678) 415-4207; fax: (678) 415-2686; e-mail: [email protected] This study was organized by Robin Chalmers, O.D., F.A.A.O., CIBA Vision Corporation, Duluth, GA, U.S.A., with support in France by Johanne Le Bihanne, CIBA Vision France, Toulouse, France. Bill Long is an employee of CIBA Vision, Duluth, GA. The authors received compensation for this study. Eye & Contact Lens: Science & Clinical Practice: January 2003 - Volume 29 - Issue 1 - p 50-54 Buy Abstract Purpose. This article reports clinical results comparing a high-oxygen permeable (HDk) silicone hydrogel soft contact lens with a low-oxygen permeable (LDk) soft hydroxyethyl methacrylate contact lens when worn on an extended-wear basis. Methods. Six practitioners in France enrolled 134 subjects in this 4-month, open-label, multicenter, prospective, randomized, cross-over study. Subjects were randomized to receive either an HDk lotrafilcon A or an LDk etafilcon A soft contact lens. Subjects crossed over to the alternative lens after either 3 months’ experience with the HDk lens or 1 month’s experience with the LDk lens. Clinical and subjective data were collected at scheduled follow-up visits. Results. The subjective data has been reported in a separate article. Both types of lenses gave similar performance for visual acuity. Biomicroscopic examination findings averaged below grade 1 (trace) for both lenses throughout the study. A statistically significant difference for limbal redness was found at 1 week (HDk = 0.11; LDk = 0.33; paired-t test, P <0.05). Eight of 10 biomicroscopic signs improved within 1 week when subjects changed from the LDk lens to the HDk lens. Deposits for both lenses remained below grade 1, and wetting was nearly perfect for both lenses throughout the study. Over 90% of fittings for both lenses were acceptable or optimal. Conclusions. The improvements in biomicroscopy signs seen with the HDk lens may provide practitioners an alternative to LDk contact lenses for extended wear. © 2003 Lippincott Williams & Wilkins, Inc.