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An Autologous Leukocyte-Reduced Platelet-Rich Plasma Therapy for Chronic Injury of the Medial Collateral Ligament in the Knee

A Report of 3 Successful Cases

Yoshida, Mamoru MD, PhD*; Marumo, Keishi MD, PhD*

Clinical Journal of Sport Medicine: January 2019 - Volume 29 - Issue 1 - p e4–e6
doi: 10.1097/JSM.0000000000000515
Case Report

Abstract: Some patients complain of chronic persistent medial knee pain after isolated low-grade injuries of medial collateral ligaments (MCL). These injuries often respond to various conservative treatments but insufficient healing of ligaments is believed to be responsible for symptoms in this group of patients. We report on successful treatment of chronically symptomatic MCL injuries in 3 patients using autologous leukocyte-reduced platelet-rich plasma (PRP) injections. There were 3 men with a mean age of 39.3 years and a mean disease duration of 10 months. Magnetic resonance imaging showed discontinuities of superficial layers and thickness of deep layers in the proximal MCL. After PRP injections, all cases returned to their sport activities at a previous level as without symptoms, and complete healing of proximal ligaments was identified on magnetic resonance images. The outcomes indicated that PRP injections led to successful repair for chronic injuries of MCL in knees.

*Department of Orthopaedic Surgery, The Jikei University School of Medicine, Tokyo, Japan.

Corresponding Author: Mamoru Yoshida, MD, PhD, Department of Orthopaedic Surgery, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan (

The authors report no conflicts of interest.

Received January 28, 2017

Accepted April 13, 2017

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