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Return to Sport After Arthroscopic Autologous Matrix-Induced Chondrogenesis for Patients With Osteochondral Lesion of the Talus

D'Ambrosi, Riccardo MD*,†; Villafañe, Jorge H. PhD, MSc; Indino, Cristian MD*; Liuni, Federico M. MD§; Berjano, Pedro PhD, MD*; Usuelli, Federico G. MD*

Clinical Journal of Sport Medicine: November 2019 - Volume 29 - Issue 6 - p 470–475
doi: 10.1097/JSM.0000000000000560
Original Research

Objective: To determine the rate of return of patients to sport after arthroscopic autologous matrix-induced chondrogenesis (AT-AMIC) for outcomes 2 years after surgery.

Design: Retrospective observational cross-sectional study.

Setting: C.A.S.C.O.—Foot and Ankle Unit, Istituto Ortopedico Galeazzi, Milan, Italy.

Patients and Intervention: Twenty-six consecutive patients, 65.4% male (mean ± SD age: 33.7 ± 11.0 years), that underwent AT-AMIC procedure between 2012 and 2015 were selected retrospectively. From this population, only sporting patients at amateur's level were included. Arthroscopic autologous matrix-induced chondrogenesis was proposed in patients with pain and persistent disability.

Main Outcome Measures: All patients were assessed with the American Orthopaedic Foot and Ankle Score (AOFAS), physical component score of the 12-Item Short Form Health Survey (SF-12), Halasi ankle activity score, and University of California, Los Angeles (UCLA) activity scale preoperatively and at 24 months postoperatively.

Results: Overall, 80.8% of the patient group returned to the same preinjury sport. The mean follow-up was 42.6 ± 10.9 months (range from 25 to 62 months). Significant differences were observed with reference to AOFAS, SF-12, Halasi, and UCLA scores at the last follow-up in patients who had undergone AT-AMIC (all, P < 0.001).

Conclusions: A high percentage of patients return to their preinjury sport after AT-AMIC surgery.

*IRCCS Istituto Ortopedico Galeazzi, C.A.S.C.O. - Foot and Ankle Unit, Milan, Italy;

Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy;

IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy; and

§Dipartimento di Ortopedia e Traumatologia, Ospedale Santa Maria, Borgo Val di Taro, Parma, Italy.

Corresponding Author: Riccardo D'Ambrosi, MD, IRCCS Istituto Ortopedico Galeazzi, C.A.S.C.O - Foot and Ankle Unit, Via Galeazzi 4, 20161 Milan, Italy (

F. G. Usuelli reports personal fees from Integra and Geistlich and grants and personal fees from Zimmer, outside the submitted work. The remaining authors report no conflicts of interest.

This research protocol has been approved by the Local Ethics Committee.

Informed consent was obtained from all participants and procedures were conducted according to the Declaration of Helsinki.

Received July 04, 2017

Accepted November 14, 2017

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