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Clinical and MRI Outcomes After Platelet-Rich Plasma Treatment for Knee Osteoarthritis

Halpern, Brian MD; Chaudhury, Salma MD, PhD, MRC; Rodeo, Scott A. MD; Hayter, Catherine MD; Bogner, Eric MD; Potter, Hollis G. MD; Nguyen, Joseph MPH

Clinical Journal of Sport Medicine: May 2013 - Volume 23 - Issue 3 - p 238–239
doi: 10.1097/JSM.0b013e31827c3846
Case Report

Abstract: The purpose of this study was to investigate whether platelet-rich plasma therapy for early knee osteoarthritis is associated with good clinical outcomes and a change in magnetic resonance imaging (MRI) structural appearances. The design was a prospective cohort study following patients 1 year after platelet-rich plasma therapy for knee osteoarthritis. Twenty-two patients were treated with platelet-rich plasma for early osteoarthritis, confirmed with a baseline MRI. Inclusion criteria were Kellgren grade 0–II with knee pain in patients aged 30 to 70 years. All the patients received a 6-mL platelet-rich plasma injection using the Cascade system. Fifteen subjects underwent clinical assessments at baseline, 1 week, and 1, 3, 6, and 12 months, and MRIs at 1 year. Pain scores significantly decreased, whereas functional and clinical scores increased at 6 months and 1 year from baseline. Qualitative MRIs demonstrated no change per compartment in at least 73% of cases at 1 year.

Hospital for Special Surgery, New York, New York.

Corresponding Author: Brian Halpern, MD, Hospital for Special Surgery, 535 East 70th St, New York, NY 10021 (

The authors report no funding or conflicts of interest.

Institutional review board approval for the study was received.

Received June 19, 2012

Accepted November 01, 2012

© 2013 by Lippincott Williams & Wilkins