Original Article: Chronic Kidney Disease

Symptom Burden before and after Dialysis Initiation in Older Patients

de Rooij, Esther N.M.^1,2; Meuleman, Yvette¹; de Fijter, Johan W.²; Jager, Kitty J.³; Chesnaye, Nicholas C.³; Evans, Marie⁴; Caskey, Fergus J.⁵; Torino, Claudia⁶; Porto, Gaetana⁷; Szymczak, Maciej⁸; Drechsler, Christiane⁹; Wanner, Christoph⁹; Dekker, Friedo W.¹; Hoogeveen, Ellen K.^1,2,10,* on behalf of the EQUAL study investigators

Collaborators

Schneider, Andreas; Torp, Anke; Iwig, Beate; Perras, Boris; Marx, Christian; Drechsler, Christiane; Blaser, Christof; Wanner, Christoph; Emde, Claudia; Krieter, Detlef; Fuchs, Dunja; Irmler, Ellen; Platen, Eva; Schmidt-Gürtler, Hans; Schlee, Hendrik; Naujoks, Holger; Schlee, Ines; Cäsar, Sabine; Beige, Joachim; Röthele, Jochen; Mazur, Justyna; Hahn, Kai; Blouin, Katja; Neumeier, Katrin; Anding-Rost, Kirsten; Schramm, Lothar; Hopf, Monika; Wuttke, Nadja; Frischmuth, Nikolaus; Ichtiaris, Pawlos; Kirste, Petra; Schulz, Petra; Aign, Sabine; Biribauer, Sandra; Manan, Sherin; Röser, Silke; Heidenreich, Stefan; Palm, Stephanie; Schwedler, Susanne; Delrieux, Sylke; Renker, Sylvia; Schättel, Sylvia; Stephan, Theresa; Schmiedeke, Thomas; Weinreich, Thomas; Leimbach, Til; Stövesand, Torsten; Bahner, Udo; Seeger, Wolfgang; Cupisti, Adamasco; Sagliocca, Adelia; Ferraro, Alberto; Mele, Alessandra; Naticchia, Alessandro; Còsaro, Alex; Ranghino, Andrea; Stucchi, Andrea; Pignataro, Angelo; De Blasio, Antonella; Pani, Antonello; Tsalouichos, Aris; Antonio, Bellasi; Di Iorio, Biagio Raffaele; Alessandra, Butti; Abaterusso, Cataldo; Somma, Chiara; D’alessandro, Claudia; Torino, Claudia; Zullo, Claudia; Pozzi, Claudio; Bergamo, Daniela; Ciurlino, Daniele; Motta, Daria; Russo, Domenico; Favaro, Enrico; Vigotti, Federica; Ansali, Ferruccio; Conte, Ferruccio; Cianciotta, Francesca; Giacchino, Francesca; Cappellaio, Francesco; Pizzarelli, Francesco; Greco, Gaetano; Porto, Gaetana; Bigatti, Giada; Marinangeli, Giancarlo; Cabiddu, Gianfranca; Fumagalli, Giordano; Caloro, Giorgia; Piccoli, Giorgina; Capasso, Giovanbattista; Gambaro, Giovanni; Tognarelli, Giuliana; Bonforte, Giuseppe; Conte, Giuseppe; Toscano, Giuseppe; Del Rosso, Goffredo; Capizzi, Irene; Baragetti, Ivano; Oldrizzi, Lamberto; Gesualdo, Loreto; Biancone, Luigi; Magnano, Manuela; Ricardi, Marco; Di Bari, Maria; Laudato, Maria; Sirico, Maria Luisa; Ferraresi, Martina; Provenzano, Michele; Malaguti, Moreno; Palmieri, Nicola; Murrone, Paola; Cirillo, Pietro; Dattolo, Pietro; Acampora, Pina; Nigro, Rita; Boero, Roberto; Scarpioni, Roberto; Sicoli, Rosa; Malandra, Rosella; Savoldi, Silvana; Bertoli, Silvio; Borrelli, Silvio; Maxia, Stefania; Maffei, Stefano; Mangano, Stefano; Cicchetti, Teresa; Rappa, Tiziana; Palazzo, Valentina; De Simone, Walter; Schrander, Anita; van Dam, Bastiaan; Siegert, Carl; Gaillard, Carlo; Beerenhout, Charles; Verburgh, Cornelis; Janmaat, Cynthia; Hoogeveen, Ellen; Hoorn, Ewout; Dekker, Friedo; Boots, Johannes; Boom, Henk; Eijgenraam, Jan-Willem; Kooman, Jeroen; Rotmans, Joris; Jager, Kitty; Vogt, Liffert; Raasveld, Maarten; Vervloet, Marc; van Buren, Marjolijn; van Diepen, Merel; Chesnaye, Nicholas; Leurs, Paul; Voskamp, Pauline; Blankestijn, Peter; van Esch, Sadie; Boorsma, Siska; Berger, Stefan; Konings, Constantijn; Aydin, Zeynep; Musiała, Aleksandra; Szymczak, Anna; Olczyk, Ewelina; Augustyniak-Bartosik, Hanna; Miśkowiec-Wiśniewska, Ilona; Manitius, Jacek; Pondel, Joanna; Jędrzejak, Kamila; Nowańska, Katarzyna; Nowak, Łukasz; Szymczak, Maciej; Durlik, Magdalena; Dorota, Szyszkowska; Nieszporek, Teresa; Heleniak, Zbigniew; Jonsson, Andreas; Blom, Anna-Lena; Rogland, Björn; Wallquist, Carin; Vargas, Denes; Dimény, Emöke; Sundelin, Fredrik; Uhlin, Fredrik; Welander, Gunilla; Hernandez, Isabel Bascaran; Gröntoft, Knut-Christian; Stendahl, Maria; Svensson, Maria; Evans, Marie; Heimburger, Olof; Kashioulis, Pavlos; Melander, Stefan; Almquist, Tora; Jensen, Ulrika; Woodman, Alistair; McKeever, Anna; Ullah, Asad; McLaren, Barbara; Harron, Camille; Barrett, Carla; O'Toole, Charlotte; Summersgill, Christina; Geddes, Colin; Glowski, Deborah; McGlynn, Deborah; Sands, Dympna; Caskey, Fergus; Roy, Geena; Hirst, Gillian; King, Hayley; McNally, Helen; Masri-Senghor, Houda; Murtagh, Hugh; Rayner, Hugh; Turner, Jane; Wilcox, Joanne; Berdeprado, Jocelyn; Wong, Jonathan; Banda, Joyce; Jones, Kirsteen; Haydock, Lesley; Wilkinson, Lily; Carmody, Margaret; Weetman, Maria; Joinson, Martin; Dutton, Mary; Matthews, Michael; Morgan, Neal; Bleakley, Nina; Cockwell, Paul; Roderick, Paul; Mason, Phil; Kalra, Philip; Sajith, Rincy; Chapman, Sally; Navjee, Santee; Crosbie, Sarah; Brown, Sharon; Tickle, Sheila; Mathavakkannan, Suresh; Kuan, Ying

Author Information

¹Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

²Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands

³European Renal Association Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam, The Netherlands

⁴Renal Unit, Department of Clinical Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden

⁵Population Health Sciences, University of Bristol, Bristol, United Kingdom

⁶National Research Council – Institute of Clinical Physiology, Reggio Calabria, Italy

⁷Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria, Italy

⁸Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland

⁹Division of Nephrology, University Hospital of Würzburg, Würzburg, Germany

¹⁰Department of Nephrology, Jeroen Bosch Hospital, Den Bosch, The Netherlands

^*EQUAL study investigators: Andreas Schneider, Anke Torp, Beate Iwig, Boris Perras, Christian Marx, Christiane Drechsler, Christof Blaser, Christoph Wanner, Claudia Emde, Detlef Krieter, Dunja Fuchs, Ellen Irmler, Eva Platen, Hans Schmidt-Gürtler, Hendrik Schlee, Holger Naujoks, Ines Schlee, Sabine Cäsar, Joachim Beige, Jochen Röthele, Justyna Mazur, Kai Hahn, Katja Blouin, Katrin Neumeier, Kirsten Anding-Rost, Lothar Schramm, Monika Hopf, Nadja Wuttke, Nikolaus Frischmuth, Pawlos Ichtiaris, Petra Kirste, Petra Schulz, Sabine Aign, Sandra Biribauer, Sherin Manan, Silke Röser, Stefan Heidenreich, Stephanie Palm, Susanne Schwedler, Sylke Delrieux, Sylvia Renker, Sylvia Schättel, Theresa Stephan, Thomas Schmiedeke, Thomas Weinreich, Til Leimbach, Torsten Stövesand, Udo Bahner, Wolfgang Seeger, Adamasco Cupisti, Adelia Sagliocca, Alberto Ferraro, Alessandra Mele, Alessandro Naticchia, Alex Còsaro, Andrea Ranghino, Andrea Stucchi, Angelo Pignataro, Antonella De Blasio, Antonello Pani, Aris Tsalouichos, Bellasi Antonio, Biagio Raffaele Di Iorio, Butti Alessandra, Cataldo Abaterusso, Chiara Somma, Claudia D’alessandro, Claudia Torino, Claudia Zullo, Claudio Pozzi, Daniela Bergamo, Daniele Ciurlino, Daria Motta, Domenico Russo, Enrico Favaro, Federica Vigotti, Ferruccio Ansali, Ferruccio Conte, Francesca Cianciotta, Francesca Giacchino, Francesco Cappellaio, Francesco Pizzarelli, Gaetano Greco, Gaetana Porto, Giada Bigatti, Giancarlo Marinangeli, Gianfranca Cabiddu, Giordano Fumagalli, Giorgia Caloro, Giorgina Piccoli, Giovanbattista Capasso, Giovanni Gambaro, Giuliana Tognarelli, Giuseppe Bonforte, Giuseppe Conte, Giuseppe Toscano, Goffredo Del Rosso, Irene Capizzi, Ivano Baragetti, Lamberto Oldrizzi, Loreto Gesualdo, Luigi Biancone, Manuela Magnano, Marco Ricardi, Maria Di Bari, Maria Laudato, Maria Luisa Sirico, Martina Ferraresi, Michele Provenzano, Moreno Malaguti, Nicola Palmieri, Paola Murrone, Pietro Cirillo, Pietro Dattolo, Pina Acampora, Rita Nigro, Roberto Boero, Roberto Scarpioni, Rosa Sicoli, Rosella Malandra, Silvana Savoldi, Silvio Bertoli, Silvio Borrelli, Stefania Maxia, Stefano Maffei, Stefano Mangano, Teresa Cicchetti, Tiziana Rappa, Valentina Palazzo, Walter De Simone, Anita Schrander, Bastiaan van Dam, Carl Siegert, Carlo Gaillard, Charles Beerenhout, Cornelis Verburgh, Cynthia Janmaat, Ellen Hoogeveen, Ewout Hoorn, Friedo Dekker, Johannes Boots, Henk Boom, Jan-Willem Eijgenraam, Jeroen Kooman, Joris Rotmans, Kitty Jager, Liffert Vogt, Maarten Raasveld, Marc Vervloet, Marjolijn van Buren, Merel van Diepen, Nicholas Chesnaye, Paul Leurs, Pauline Voskamp, Peter Blankestijn, Sadie van Esch, Siska Boorsma, Stefan Berger, Constantijn Konings, Zeynep Aydin, Aleksandra Musiała, Anna Szymczak, Ewelina Olczyk, Hanna Augustyniak-Bartosik, Ilona Miśkowiec-Wiśniewska, Jacek Manitius, Joanna Pondel, Kamila Jędrzejak, Katarzyna Nowańska, Łukasz Nowak, Maciej Szymczak, Magdalena Durlik, Szyszkowska Dorota, Teresa Nieszporek, Zbigniew Heleniak, Andreas Jonsson, Anna-Lena Blom, Björn Rogland, Carin Wallquist, Denes Vargas, Emöke Dimény, Fredrik Sundelin, Fredrik Uhlin, Gunilla Welander, Isabel Bascaran Hernandez, Knut-Christian Gröntoft, Maria Stendahl, Maria Svensson, Marie Evans, Olof Heimburger, Pavlos Kashioulis, Stefan Melander, Tora Almquist, Ulrika Jensen, Alistair Woodman, Anna McKeever, Asad Ullah, Barbara McLaren, Camille Harron, Carla Barrett, Charlotte O'Toole, Christina Summersgill, Colin Geddes, Deborah Glowski, Deborah McGlynn, Dympna Sands, Fergus Caskey, Geena Roy, Gillian Hirst, Hayley King, Helen McNally, Houda Masri-Senghor, Hugh Murtagh, Hugh Rayner, Jane Turner, Joanne Wilcox, Jocelyn Berdeprado, Jonathan Wong, Joyce Banda, Kirsteen Jones, Lesley Haydock, Lily Wilkinson, Margaret Carmody, Maria Weetman, Martin Joinson, Mary Dutton, Michael Matthews, Neal Morgan, Nina Bleakley, Paul Cockwell, Paul Roderick, Phil Mason, Philip Kalra, Rincy Sajith, Sally Chapman, Santee Navjee, Sarah Crosbie, Sharon Brown, Sheila Tickle, Suresh Mathavakkannan, and Ying Kuan.

Correspondence: Dr. Esther N.M. de Rooij, Department of Nephrology, Leiden University Medical Center (Building 1, C7-Q), Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Email: [email protected]

CJASN 17(12):p 1719-1729, December 2022. | DOI: 10.2215/CJN.09190822