Renal PhysiologyThe Glomerulus The Sphere of InfluencePollak, Martin R.*; Quaggin, Susan E.†; Hoenig, Melanie P.*; Dworkin, Lance D.‡ Author Information *Beth Israel Deaconess Medical Center, Boston, Massachusetts; †Feinberg School of Medicine, Northwestern University, Chicago, Illinois; and ‡Brown Medical School, Brown University, Providence, Rhode Island Correspondence: Dr. Martin Pollak, Beth Israel Deaconess Medical Center, West Campus/Farr 8, 185 Pilgrim Road, Boston, MA 02215. Email: [email protected] Clinical Journal of the American Society of Nephrology 9(8):p 1461-1469, August 2014. | DOI: 10.2215/CJN.09400913 Buy Metrics Abstract The glomerulus, the filtering unit of the kidney, is a unique bundle of capillaries lined by delicate fenestrated endothelia, a complex mesh of proteins that serve as the glomerular basement membrane and specialized visceral epithelial cells that form the slit diaphragms between interdigitating foot processes. Taken together, this arrangement allows continuous filtration of the plasma volume. The dynamic physical forces that determine the single nephron glomerular filtration are considered. In addition, new insights into the cellular and molecular components of the glomerular tuft and their contribution to glomerular disorders are explored. Copyright © 2014 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.