The femoral intercondylar notch is a complex 3-dimensional space that can be difficult to evaluate using 2-dimensional images. Normal structures residing in the femoral intercondylar notch are the cruciate ligaments. Several normal variants also course through the femoral intercondylar notch, including the meniscofemoral ligament, intermeniscal ligament, oblique meniscomeniscal ligament, and infrapatellar plica. Abnormalities within the femoral intercondylar notch include internal derangements (i.e., cruciate ligament rupture and bucket-handle meniscal tears) and masses (i.e., intra-articular ganglion [cyst], intra-articular body, pigmented villonodular synovitis, arthrofibrosis, and synovial hemangioma). Radiologic signs can signify abnormalities within the femoral intercondylar notch or elsewhere in the knee, including empty notch sign, double posterior cruciate ligament sign, double anterior cruciate ligament sign, and reversed double posterior cruciate ligament sign. The shape of the femoral intercondylar notch and the presence of meniscal variants can be predictors of future pathology. This article discusses the anatomy and pathology of the femoral intercondylar notch.