Original ArticlesPathophysiology of COPDLeap, Jennifer DO; Arshad, Obaid MD; Cheema, Tariq MD, FCCP, MMM; Balaan, Marvin MDAuthor Information Division of Pulmonary Critical Care Medicine, Allegheny Health Network, Allegheny General Hospital, Pittsburgh, Pennsylvania. Correspondence: Tariq Cheema, MD, FCCP, MMM, Pulmonary Lab, Division of Pulmonary Critical Care Medicine, Allegheny Health Network, Allegheny General Hospital, 320 East North Ave, Pittsburgh, PA 15212 ([email protected]). Dr Tariq Cheema serves on the speaker's bureau for Boehringer Ingelheim and GSK and is a consultant for Noveme Biotherapeutics Inc. The other authors have no conflicts of interest to declare. Critical Care Nursing Quarterly: January/March 2021 - Volume 44 - Issue 1 - p 2-8 doi: 10.1097/CNQ.0000000000000334 Buy Metrics Abstract This article provides an overview of the pathophysiology of chronic obstructive pulmonary disease including the physiological mechanisms that are known precursors. The roles of environmental and genetic causes are considered. α1-Antitrypsin deficiency is also discussed as it relates to the development of airflow obstruction. © 2021 Wolters Kluwer Health, Inc. All rights reserved.